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MetabolomicsMass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies,...

2023-05-23 | MTBLS7565 | MetaboLights
ProteomicsMulti-omic analysis of guided and unguided forebrain organoids
Neural organoids are invaluable model systems for studying neurodevelopment and neurological diseases. For this purpose, reproducible differentiation protocols are needed that minimize inter-organoid variability whilst generating neural organoids that physiologically resemble the brain area of inter...
ORGANISM(S): Homo sapiens (Human) 
2026-02-25 | PXD048559 | Pride
Human Organoids Orbitrap exploris Forebrain Sialylation Phosphorylation 
TranscriptomicsSingle-cell RNA sequencing data of human dorsal forebrain organoids derived from three iPSC lines
This dataset contains single-cell RNA sequencing data generated from nine dorsal forebrain organoids collected at day 90 of differentiation. The organoids were derived from three human induced pluripotent stem cell lines: KOLF2.1J, BIONi010-C, and HMGU1. The primary objective of the study was to exp...
ORGANISM(S): Homo sapiens 
2026-08-03 | E-MTAB-17432 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcription profiling human dorsal forebrain organoids treated with Hyper-IL-6
We performed single-cell RNA sequencing of dorsal forebrain organoids at day 53 of differentiation upon treatment with Hyper-IL-6. The study aimed at investigation of the effects of Hyper-IL-6 on transcriptional profiles of dorsal forebrain organoids at single-cell level.
ORGANISM(S): Homo sapiens 
2023-03-08 | E-MTAB-12743 | biostudies-arrayexpress
TranscriptomicsRNA-seq of INPP5E mutant cortical organoids against control organoids
Primary cilia act as antennas in cell-cell signalling and are crucial for nervous system development. We explored their role in the development of the human cerebral cortex using organoids defective for the ciliary gene INPP5E. We investigated the transcription profile of control and INPP5ED477N/D47...
ORGANISM(S): Homo sapiens 
2022-06-06 | E-MTAB-11437 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human dorsal forebrain organoids treated with Hyper-IL-6
Description: RNA-seq of total RNA isolated from dorsal forebrain organoids at days 50 and 55 of differentiation. The study aimed at investigating the effects of 5 or 10 days of Hyper-IL-6 exposure on transcriptional profiles of dorsal forebrain organoids.
ORGANISM(S): Homo sapiens 
2023-03-08 | E-MTAB-12702 | biostudies-arrayexpress
GenomicsImpact of KIF26A loss in human forebrain organoids
Impact of KIF26A loss in human forebrain organoids
PRJNA880567 | ENA
GenomicsSingle cell RNA-sequencing of 90-day old astrocyte conditioned medium treated forebrain organoids (ACMOs) and control forebrain organoids
Single cell RNA-sequencing of 90-day old astrocyte conditioned medium treated forebrain organoids (ACMOs) and control forebrain organoids
PRJNA1144131 | ENA
GenomicsBulk RNA sequencing of human forebrain organoids following Aβ42 treatment
Bulk RNA sequencing of human forebrain organoids following Aβ42 treatment
PRJNA1498598 | ENA
GenomicsTranscription profiling of human dorsal forebrain organoids treated with Hyper-IL-6
Transcription profiling of human dorsal forebrain organoids treated with Hyper-IL-6
PRJEB60352 | ENA
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