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GenomicsIdentification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during lens and forebrain development
The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain (HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and in specific subpopulations of neurons; absence of Pax6 results in disrupted cell proliferation and cell fate specification...
ORGANISM(S): Mus musculus 
2015-07-09 | E-GEOD-66961 | biostudies-arrayexpress
ProteomicsSuccinyl-CoA synthetase deficiency in mouse forebrain results in hyper-succinylation with perturbed neuronal transcriptional regulation and metabolism
Lysine-succinylation is a subtype of protein acylation associated with metabolic regulation of succinyl-CoA in the TCA cycle. Deficiency of succinyl-CoA synthetase (SCS), the TCA-cycle enzyme catalyzing the reversible conversion of succinyl-CoA to succinate, leads to mitochondrial encephalomyopathy ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-06-21 | MSV000089697 | MassIVE
ProteomicsMulti-omic analysis of guided and unguided forebrain organoids
Neural organoids are invaluable model systems for studying neurodevelopment and neurological diseases. For this purpose, reproducible differentiation protocols are needed that minimize inter-organoid variability whilst generating neural organoids that physiologically resemble the brain area of inter...
ORGANISM(S): Homo sapiens (Human) 
2026-02-25 | PXD048559 | Pride
Human Organoids Orbitrap exploris Forebrain Sialylation Phosphorylation 
TranscriptomicsTranscription profiling of microdissected and hand sorted mouse forebrain neurons to understand the extend and nature of differential expression in various cell types.
The mammalian forebrain is a tissue of stunning complexity comprised of numerous regions each containing many distinct cell types that differ in their intrinsic and synaptic physiology, morphology and connectivity. These differences are likely conferred by differential gene expression, but the exte...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2882 | biostudies-arrayexpress
TranscriptomicsExpression data in the mouse brain following the glucocorticoid receptor overexpression in the forebrain (GRov) during different periods in development
The glucocorticoid receptor overexpression in early life is sufficient to alter gene expression patterns for the rest of the animal's life. Hippocampal dentate gyrus (DG) are more responsive than the nucleus accumbens (NAcc) following the glucocorticoid receptor overexpression in the forebrain. Lase...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-30187 | biostudies-arrayexpress
TranscriptomicsExpression of constitutively active FOXO3 in murine forebrain leads to a loss of neural progenitors
We have generated transgenic mice with tetracycline-regulated conditional expression of a constitutively active allele of FoxO3 under the control of the forebrain-specific CaMKIIa promoter. In adult animals, there was a reduction of brain weight by 30% and an almost complete loss of the dorsal denta...
ORGANISM(S): Mus musculus 
2012-09-13 | E-GEOD-21089 | biostudies-arrayexpress
ProteomicsProteogenomic characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling
Hyperactivated mTOR signaling in the developing brain by mutation of TSC1 genes has multiple forms of pathology including tuberous sclerosis complex (TSC). To examine the downstream networks affected in the developing brain by hyperactivated mTOR signaling, we performed an integrated analysis of tra...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-16 | PXD005768 | Pride
Lc-msms Mouse Brain Forebrain 
ProteomicsForebrain Hindbrain histone H4 Mus musculus P25 P47
Quantitative top down analysis of histone H4 proteoforms in the mouse forebrain and hindbrain at 25 and 47 days of age.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000090249 | MassIVE
ProteomicsP0 B6 mouse forebrain Ythdf2 LC-MS/MS
For P0 B6 mouse forebrain, to investigate the interacting protein partners with Ythdf2 with m6A, we compared the Mettl14 Nestin-Cre condition knockout mouse with WT mouse and changed the condition for IgG pulldown and Ythdf2 antibody pulldown.
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD080605 | Pride
Mouse Forebrain Ythdf2 Lc-ms/ms 
GenomicsUniform optimal framework for integrative next-gen sequence analysis
Here, we have collapsed multiple analysis problems into two coherent categories, signal detection and signal estimation and adapted linear-optimal solutions from signal processing theory. Our algorithms for detection (DFilter) and estimation (EFilter) extend naturally to integration of multiple data...
ORGANISM(S): Mus musculus 
2013-06-10 | E-GEOD-34073 | biostudies-arrayexpress
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