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ProteomicsA FOXN1 mutation competitively displaces wild-type FOXN1 from higher-order nuclear condensates to cause immunodeficiency
The transcription factor FOXN1 is a master regulator of thymic epithelial cell development and function. Here we demonstrate that FOXN1 expression is differentially regulated during organogenesis and participates in multi-molecular nuclear condensates essential for the factor's transcriptional activ...
ORGANISM(S): Homo sapiens (Human) 
2021-10-29 | PXD025552 | Pride
Forkhead box n1 transcription factor Thymus Immunodeficiency 
UnknownRegeneration of the aged thymus by a single transcription factor.
Not available
S-EPMC3978836 | biostudies-literature
TranscriptomicsGene expression analysis of FOXN1+ thymic endoderm cells derived from the in vitro differentiation of human embryonic stem cells
The goal of this study was to document the gene expression profile of FOXN1+ thymic endoderm cells derived from the in vitro differentiation of human pluripotent stem cells. Thymic epithelial cells (TECs) play a critical role in T-cell maturation and tolerance induction. The generation of TECs from ...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-56373 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of thymocytes from conditional knock-out mice (FoxN1-Cre mediated KO of Gpr177)
Comparative gene expression profiling of thymocytes at the DP, CD4 SP and CD8 SP stage derived from FoxN1-Gpr177 mice (FoxN1-Cre mediated deletion of (Exon3 of) Gpr177/Wtls) or C57Bl/6N mice as comparison. Objective was to test the influence of TEC-secreted Wnt ligands on the transcriptome of thymoc...
ORGANISM(S): Mus musculus 
2015-11-01 | E-GEOD-69766 | biostudies-arrayexpress
UnknownAn organized and functional thymus generated from FOXN1-reprogrammed fibroblasts.
Not available
S-EPMC4153409 | biostudies-literature
UnknownA positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans.
Not available
S-EPMC2752067 | biostudies-literature
UnknownOverexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells.
Not available
S-EPMC3228493 | biostudies-literature
UnknownFOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans.
Not available
S-EPMC6819092 | biostudies-literature
ProteomicsThe proteins binding with locust pre-miR-276
In order to investigate the proteins interacting with precusor of miR-276 (pre-miR-276), the RNA-pull down followed by mass spectrometry (MS) were performed in locust terminal oocyte extracts. The RNA oligos labeled with biotin at the 3’ end for pre-miR-276 (62 nt) and pre-miR-67 (69 nt) of C. elega...
ORGANISM(S): Locusta Migratoria 
2024-04-09 | PXD041810 |
UnknownFOXN1: A Master Regulator Gene of Thymic Epithelial Development Program.
Not available
S-EPMC3709140 | biostudies-literature
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