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MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
MetabolomicsEffects of Yulin Tong Bu formula on modulating gut microbiota and fecal metabolite interactions in mice with polycystic ovary syndrome

BACKGROUND: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism, ovarian dysfunction and polycystic ovarian morphology. Gut microbiota dysbiosis and metabolite are associated with PCOS clinical parameters. Yulin Tong Bu formula (YLT...

2023-02-02 | MTBLS6736 | MetaboLights
ProteomicsFormula Q attenuates letrozole-induced polycystic ovary syndrome through modulating multiple pathways in rat
In this research, we investigated the molecular mechanisms and signaling pathways of Formula Q attenuating PCOS using a Tandem Mass Tag (TMT) proteomics approach, bioinformatics analyses and molecular biological technology. This study aimed to comprehensively characterize the multiple molecular mech...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-05-25 | PXD057910 | Pride
Multiple pathways Formula q Proteomics Traditional chinese medicine Pcos 
UnknownSignatures of intramolecular vibrational and vibronic Q[Formula: see text]-Q[Formula: see text] coupling effects in absorption and CD spectra of chlorophyll dimers.
Not available
S-EPMC10070234 | biostudies-literature
UnknownAn Integrated Pharmacology-Based Analysis for Antidepressant Mechanism of Chinese Herbal Formula Xiao-Yao-San.
Not available
S-EPMC7094752 | biostudies-literature
ProteomicsInfant milk formula enriched in dairy cream brings its digestibility closer to human milk and supports intestinal health
Human breast milk (HBM) is the “gold standard” for infant nutrition. When breast milk is insufficient or unavailable, infant milk formula (IMF) can provide a safe and nutritious alternative. However, IMFs often differ considerably from HBM in composition, particularly fatty acid profiles, and health...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-05-06 | PXD043255 | Pride
Caco-2  infant formula  infant nutrition  milk fat globule  dairy lipids 
ProteomicsProteomic analysis of the peptic and pancreatic digests of infant formula ingredients
Whey protein and serum protein concentrate (WPC, SPC) are infant formula (IF) ingredients. SPC was produced under different processing conditions. SPC; heat-treated (80 degree, 30 s) SPC (HT-SPC); heat-treated and stored SPC (six weeks at 37 degree, HTS-SPC) were compared to a whey protein concentra...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
2022-04-22 | MSV000089298 | MassIVE
TranscriptomicsRNA-seq of human HEK-293T cells treated with a nutraceutical formula (solution-10), or vehicle-(saline solution)- control
HEK-293T cells were plated (1x106 cells) and treated with a nutraceutical formula (Solution-10) at 0.01x concentration or with vehicle (saline solution) as the negative control for the treatment. After 24 hours, the cells were lysed, and their RNA was extracted for RNAseq.
ORGANISM(S): Homo sapiens 
2026-08-14 | E-MTAB-17521 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human Caco-2 cells treated with a nutraceutical formula (solution-10), or vehicle-(saline solution)- control
Caco-2 cells were plated (1x106 cells) and treated with a nutraceutical formula (Solution-10) at 0.01x concentration or with vehicle (saline solution) as the negative control for the treatment. After 24 hours, the cells were lysed, and their RNA was extracted for RNAseq.
ORGANISM(S): Homo sapiens 
2026-08-14 | E-MTAB-17520 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human uninfected Caco-2 cells treated with a nutraceutical formula (Solution-3), or vehicle-(saline solution)- control
Caco-2 cells were plated (1000000 cells) and treated with a nutraceutical formula (Solution-3) at 0.01x concentration or with vehicle (saline solution) as the negative control for the treatment. After 24 hours, the cells were lysed, and their RNA was extracted for RNAseq.
ORGANISM(S): Homo sapiens 
2024-06-20 | E-MTAB-14178 | biostudies-arrayexpress
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