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TranscriptomicsGene expression profiles regulated by Stat5a/b vs. Stat3 in human prostate cancer cells.
Identification of the molecular changes that promote viability and metastatic behaviour of prostate cancer cells is critical for the development of improved therapeutic interventions for prostate cancer. Stat5a/b and Stat3 are both constitutively active in locally-confined and advanced prostate canc...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-17482 | biostudies-arrayexpress
TranscriptomicsUpregulation of ERBB3 by FOXD3, an adaptive response to RAF and MEK inhibitors
To understand the transcriptional impact of FOXD3 in melanoma cells, we utilized a microarray approach. We collected RNA from three unrelated mutant B-RAF melanoma cell lines (WM115, WM793, and A375) that were engineered to inducibly express FOXD3 or the control gene, ?-galactosidase (LacZ), after 5...
ORGANISM(S): Homo sapiens 
2013-03-31 | E-GEOD-43962 | biostudies-arrayexpress
TranscriptomicsA novel small-molecule inhibitor of STAT5A/STAT5B with therapeutic potential for prostate cancer and CML
We assessed the gene expression profiles induced by both genetic and pharmacological knockdown of Stat5a/b in CML cells. Stat5 was suppressed in K562 cells by lentiviral expression of Stat5 shRNA vs. scramble control for 6 days or by treatment of the cells with IST5-002 (5 µM) for 48 h. K562 cells w...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-61312 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse caveolin-3 knockout hearts
Energy Substrate Uptake and Metabolism are Preserved in Hypertrophic Caveolin-3 Knockout Hearts Experiment Overall Design: 3 wild types, 3 knockouts
ORGANISM(S): Mus musculus 
2009-03-15 | E-GEOD-10848 | biostudies-arrayexpress
TranscriptomicsTranscription profiliing of mouse caveolin-1 knockout hearts
Hearts Lacking Caveolin-1 Develop Hypertrophy with Normal Cardiac Substrate Metabolism Experiment Overall Design: 3 wild types, 3 knockouts
ORGANISM(S): Mus musculus 
2009-03-15 | E-GEOD-10849 | biostudies-arrayexpress
TranscriptomicsGenotyping of human neuroblastoma tumors
Chromosome 1p LOH was seen in one-third of cases. LOH events on chromosomes 11q and 1p were generally accompanied by copy number loss. The one exception was on chromosome 11p, where LOH in all 4 cases was accompanied by normal copy number or diploidy, implying uniparental disomy. Amplification of MY...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8333 | biostudies-arrayexpress
TranscriptomicsGene expression data from oncogene transformed murine prostate epithelial cell lines
Primary prostate epithelial cell cultures were established from the VENTRAL prostates of FVB mice . Cells were transduced with retroviral expression vectors encoding a single distinct oncogene (c-Myc, Ha-Ras (V-12), v-Src and NeuT, an activating mutant of ErbB2). Individual colonies of oncogene-t...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-37428 | biostudies-arrayexpress
TranscriptomicsStat5-regulated gene expression in human prostate cancer cells
Transcription factor Stat5 is constitutively active in human prostate cancer but not in normal prostate epithelium. Stat5 activation is associated with prostate cancer lesions of high histological grades, and is present in the majority of castration-resistant recurrent human prostate cancers. The mo...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-17483 | biostudies-arrayexpress
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