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ProteomicsTowards an upgraded honey bee (Apis mellifera L.) genome annotation using proteogenomics.
The honey bee is a key pollinator in many agricultural operations as well as a model organism for studying the genetics and evolution of social behaviour. The Apis mellifera genome has been sequenced and annotated twice over, enabling proteomics and functional genomics methods for probing relevant a...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Apis mellifera (Honeybee) Drosophila melanogaster (Fruit fly) Saccharomyces cerevisiae (Baker's yeast) Caenorhabditis elegans 
2016-01-18 | PXD002275 | Pride
Honey bees Proteogenomics Mass spectrometry Gene annotation Apis mellifera 
ProteomicsComprehensive proteomic analysis of autophagosomes derived from Leishmania infected macrophages
Autophagy has been implicated as a host defense mechanism against intracellular pathogens. However, certain intracellular pathogens such as Leishmania can manipulate the host’s autophagy to promote their survival. Recently, our findings regarding the regulation of autophagy by Leishmania donovani in...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037057 | Pride
Parasitic infection Autophagy Autophagosome Leishmania donovani Host-pathogen interactions Lcmsms 
UnknownImproving Integration of Basic Science into Clinical Medicine: Vertical Integration into Clinical Education (VICE) Activity.
Not available
S-EPMC8814280 | biostudies-literature
ProteomicsDynamic rewiring of the human interactome by interferon signalling
The type I interferon (IFN) response protects cells against viral pathogens by inducing the transcription of hundreds of IFN-stimulated genes (ISGs). Transcriptomic and biochemical approaches have established comprehensive catalogues of ISGs across species and cell types, but their antiviral mechani...
ORGANISM(S): Homo sapiens (Human) 
2020-05-15 | PXD013809 | Pride
Innate immunity Protein correlation profiling Proteomics Protein complexes Interferon stimulated gene Interferon Interactome 
ProteomicsProteomic Investigation of Neurotrophic trans-Banglene Reveals Potential Link to Iron Homeostasis
Neurodegenerative diseases remain an area where the causative disease mechanisms, with few exceptions, are poorly understood and which are very resistant to modern therapeutic advances. Current FDA-approved medications result in modest improvements in quality of life measures and no increase in life...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2024-07-04 | MSV000095252 | MassIVE
ProteomicsProteomics on spermathecal fluid of BC queens
We sampled honey bee queens from beekeepers throughout British Columbia which were rated as either 'failed' or 'healthy' by beekeepers. We performed shot-gun proteomics on the spermathecal fluid (sperm removed). Proteins were reduced, alkylated, and digested with Lys-C for 4 h in urea digestion buff...
ORGANISM(S): Apis Mellifera 
2020-03-04 | MSV000085056 | MassIVE
MetabolomicsA Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring.

BACKGROUND & AIMS: Micronutrient deficiency (MND) (ie, lack of vitamins and minerals) during pregnancy is a major public health concern. Historically, studies have considered micronutrients in isolation; however, MNDs rarely occur alone. The impact of co-occurring MNDs on pu...

2024-10-18 | MTBLS3476 | MetaboLights
ProteomicsCharacterization of Argonaute-containing protein complexes in Leishmania-infected human macrophages
Leishmania donovani, an intracellular protozoan parasite, is the causative agent of visceral leishmaniasis or kala-azar, the most severe form of leishmaniasis in humans. To date, our understanding of the molecular mechanisms associated with the pathogenicity of Leishmania infection is still limited....
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037042 | Pride
Leishmania Rnai Macrophage Lcmsms 
UnknownGenetic Dissection of the Type VI Secretion System in Acinetobacter and Identification of a Novel Peptidoglycan Hydrolase, TagX, Required for Its Biogenesis.
Not available
S-EPMC5061870 | biostudies-literature
UnknownDeveloping an Online Tool to Promote Safe Sun Behaviors With Young Teenagers as Co-researchers.
Not available
S-EPMC8521794 | biostudies-literature
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