Sort   by:  
 Page size 
ProteomicsKRAS mutation-selective requirement for ACSS2 in colorectal adenoma formation
Oncogenic KRAS mutations are prevalent in colorectal cancer (CRC) and are associated with poor prognosis and resistance to therapy. There is a substantial diversity of KRAS mutant alleles observed in CRC. Emerging clinical and experimental analysis of common KRAS mutations suggest that each mutation...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-02 | PXD050157 | Pride
Colorectal cancer Kras Acss2 
ProteomicsUnique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
RAC1P29S is the third most prevalent hotspot mutation in sun-exposed melanoma. RAC1 alterations in cancer are correlated with poor prognosis, resistance to standard chemotherapy, and insensitivity to targeted inhibitors. Although RAC1P29S mutations in melanoma and RAC1 alterations in several other c...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-18 | PXD046960 | Pride
Pd-1 Rac1 Melanoma Cdk9 
UnknownFGFR1/FOXM1 pathway: a key regulator of glioblastoma stem cells radioresistance and a prognosis biomarker.
Not available
S-EPMC6114977 | biostudies-literature
TranscriptomicsMyeloid Derived Suppressor Cells and Cancer
Transcriptional profiling of FACS-sorted and splenic control mouse cells, comparing splenic cells from FVBneuN vs Neu+ expressing FVBneuN mice with Gr1+ CD11b+ sorted tumor-infiltrating mononuclear or splenic myeloid-derived suppressor cells 4 groups or conditions. Biological replicates: 2 or 3 per ...
ORGANISM(S): Mus musculus 
2010-12-29 | E-GEOD-26289 | biostudies-arrayexpress
UnknownEfficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial.
Not available
S-EPMC3675695 | biostudies-literature
TranscriptomicsInduced Sputum Genes Associated With Spirometroc and Radiological Disease Severity in COPD Ex-smokers
Induced sputum is used to sample inflammatory cells, predominantly neutrophils and macrophages, from the airways of COPD patients. Our aim was to identify candidate genes associated with the degree of airflow obstruction and the extent of emphysema by expression profiling, and then to confirm these ...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-22148 | biostudies-arrayexpress
TranscriptomicsThe Folliculin-Fnip1 pathway deleted in human Birt-Hogg-Dube syndrome is required for B cell development.
Birt-Hogg-Dube (BHD) syndrome is an autosomal dominant disorder characterized by hamartomas of skin follicles, cystic lung disease, and renal neoplasia. Affected individuals carry heterozygous mutations in Folliculin (FLCN), a tumor suppressor gene that becomes biallelically inactivated in kidney t...
ORGANISM(S): Mus musculus 
2012-06-16 | E-GEOD-38741 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse islet of Langerhans with FoxA1/A2 knock outs
RNAs were extracted from 10 week adult control and FoxA1/A2 Pdx1CreERT2 mice. FoxA1 and FoxA2 are ablated in adult mouse Beta cells by tamoxifen adminstration. We aim to study the roles of FoxA1 and FoxA2 on islet gene expression when they are knocked down.
ORGANISM(S): Mus musculus 
2010-06-23 | E-MTAB-219 | biostudies-arrayexpress
GenomicsChIP-Seq of human normal pancreatic islets with anti-histone antibodies to analyse histone modifications
This experiment used ChIP-seq technology to create a genome-wide profile of histone marks in normal human pancreatic islets. In the current work we analyzed two histone marks associated with gene expression (H3K4me3, H3K4me1) and marks associated with gene repression(H3K27me3). Each mark was anayze...
ORGANISM(S): Homo sapiens 
2010-02-18 | E-MTAB-189 | biostudies-arrayexpress
UnknownInstitutional clinical trial accrual volume and survival of patients with head and neck cancer.
Not available
S-EPMC4279235 | biostudies-literature
Sort   by:  
 Page size