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TranscriptomicsTranscription profiling of FOXL2 over-expression in human KGN cells
In order to identify novel FOXL2 targets, we have transfected KGN cells using an expression vector containing the coding sequence of FOXL2 or, as a reference, the empty vector (mock transfection). The transcriptome perturbation induced by FOXL2 overexpression was then followed by DNA chips (i.e. FOX...
ORGANISM(S): Homo sapiens 
2007-03-02 | E-MEXP-985 | biostudies-arrayexpress
ProteomicsCRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compounds
FOXL2 is a transcription factor that plays a key role in sex determination, ovary development and maintenance. Mutations related to this gene have been described in syndromes involving premature ovarian failure and granulosa cell tumors. This kind of rare cancer (less than 5% of diagnosed ovarian ca...
ORGANISM(S): Homo sapiens (Human) 
2025-03-15 | PXD053682 | Pride
Tmt Rare cancer Crispr Granulosa cell tumor Proteomics Foxl2 
UnknownpSTAT3 activation of Foxl2 initiates the female pathway underlying temperature-dependent sex determination.
Not available
S-EPMC11406301 | biostudies-literature
UnknownSUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies.
Not available
S-EPMC3192040 | biostudies-literature
TranscriptomicsModification of the transcription factor FOXL2 at serines 101 and 107 disables DNA binding, leads to nucleolar relocalization, and rewires granulosa-cell programs
We demonstrate that FOXL2 is phosphorylated by PKC in vitro on several residues and that these modifications alter FOXL2 localization and activity. Specifically, phosphorylation of the FHD residues Ser101 and Ser107 by PKC are expected to lead to major changes in FOXL2 properties. Consistently, the ...
ORGANISM(S): Homo sapiens 
2026-08-06 | GSE309889 | GEO
UnknownComparative transcriptome analysis reveals involvement of FOXL2 in regulation of ovulation cycle in chicken.
Not available
S-EPMC12281005 | biostudies-literature
GenomicsModification of the transcription factor FOXL2 at serines 101 and 107 disables DNA binding, leads to nucleolar relocalization, and rewires granulosa-cell programs
Modification of the transcription factor FOXL2 at serines 101 and 107 disables DNA binding, leads to nucleolar relocalization, and rewires granulosa-cell programs
PRJNA1363948 | ENA
UnknownFOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development.
Not available
S-EPMC4484779 | biostudies-literature
TranscriptomicsFOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development
The Forkhead Box, FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivation of the Foxo1 and Foxo3 genes in murine ovarian granulosa cells severely impairs follicular development and apoptosis causing infertility, and as shown herein, granulosa cel...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-67662 | biostudies-arrayexpress
UnknownExtracellular vesicles derived from differentiated granulosa-like cells restore the ovarian function of rats with premature ovarian insufficiency.
Not available
S-EPMC12832956 | biostudies-literature
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