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ProteomicsPARP7-mediated ADP-ribosylation stabilizes FRA1 and restrains IRF3/IRF1-dependent apoptosis and immune signaling and in cancer cells
PARP7 inhibitors suppress tumor growth in a cell autonomous manner and by activating the immune system through restoring immune signaling. Nevertheless, the targets of PARP7-mediated ADP-ribosylation that regulate innate immune signaling and cancer cell survival remain elusive. Here, we identified P...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041870 | Pride
Adp-ribosylation Lung cancer Parp7 Fra1 
TranscriptomicsFra1 silencing in MDA-MB-231 cells
Fra1 silencing in MDA-MB-231 cells
ORGANISM(S): Homo sapiens 
2013-07-24 | E-MTAB-1230 | biostudies-arrayexpress
GenomicsFosl1/FRA1 and pancreatic cancer
AP1/Fra1 confers resistance of pancreatic cancer cells to inhibitors of the MAPK cascade
PRJEB52257 | ENA
TranscriptomicsRNAi knockdown of Fra1 in human mammary adenocardinoma using two sh-RNA constructs
Fra1 expression in LM2 cells (MDA-MB-231 derivatives, clone 4173 obtained from J. Massague) was silenced using two independent lentiviral sh-RNA constructs. Gene expresssion levels were compared to those in control cells transduced with empty vector.
ORGANISM(S): Homo sapiens 
2010-01-01 | E-NCMF-27 | biostudies-arrayexpress
GenomicsFRA1 drives melanoma metastasis through an actionable transcriptional network
FRA1 drives melanoma metastasis through an actionable transcriptional network
PRJNA1246181 | ENA
GenomicsTranscriptional changes by RBN-2397 treatment and FRA1 knockdown in NCI-H1975 cells
Transcriptional changes by RBN-2397 treatment and FRA1 knockdown in NCI-H1975 cells
PRJNA955271 | ENA
TranscriptomicsFRA1 drives melanoma metastasis through an actionable transcriptional network
Transcriptional dysregulation has emerged as a critical driver of melanoma progression, yet the molecular mechanisms governing this process and their potential as therapeutic targets remain inadequately characterized. Here, we identify FRA1 as a potent and actionable driver of melanoma metastasis. F...
ORGANISM(S): Homo sapiens 
2025-07-30 | GSE293767 | GEO
UnknownFRA1 drives melanoma metastasis through an actionable transcriptional network.
Not available
S-EPMC12669035 | biostudies-literature
UnknownFRA1 drives melanoma metastasis through an actionable transcriptional network.
Not available
S-EPMC12258986 | biostudies-literature
UnknownAP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer.
Not available
S-EPMC9763154 | biostudies-literature
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