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MetabolomicsMetabolic responses induced by DNA damage and poly (ADP-ribose) polymerase (PARP) inhibition in MCF-7 cells
Genomic instability is one of the hallmarks of cancer. Several chemotherapeutic drugs and radiotherapy induce DNA damage to prevent cancer cell replication. Cells in turn activate different DNA damage response (DDR) pathways to either repair the damage or induce cell death. These DDR pathways also e...
2015-08-01 | MTBLS177 | MetaboLights
ProteomicsA whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Inhibitors directed towards PARP1 and PARP2 are approved agents for the treatment of BRCA-related cancers. Other members of the PARP family have also been implicated in cancer and are being assessed as therapeutic targets in cancer and other diseases. In fact, an inhibitor of PARP7 (RBN-2397) has no...
ORGANISM(S): Homo sapiens (Human) 
2022-04-06 | PXD028733 | Pride
Human Turboid Parp7 
ProteomicsPARP7-mediated ADP-ribosylation stabilizes FRA1 and restrains IRF3/IRF1-dependent apoptosis and immune signaling and in cancer cells
PARP7 inhibitors suppress tumor growth in a cell autonomous manner and by activating the immune system through restoring immune signaling. Nevertheless, the targets of PARP7-mediated ADP-ribosylation that regulate innate immune signaling and cancer cell survival remain elusive. Here, we identified P...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041870 | Pride
Adp-ribosylation Lung cancer Parp7 Fra1 
GenomicsSingle-nucleus transcriptomics of Parp7-/- lung
Single-nucleus transcriptomics of Parp7-/- lung
PRJNA1425966 | ENA
GenomicsTranscriptional changes by PARP7 inhibitor in cancer cell lines
Transcriptional changes by PARP7 inhibitor in cancer cell lines
PRJNA737116 | ENA
UnknownQuantification of PARP7 Protein Levels and PARP7 Inhibitor Target Engagement in Cells Using a Split Nanoluciferase System.
Not available
S-EPMC10289056 | biostudies-literature
TranscriptomicsSingle-nucleus transcriptomics of Parp7-/- lung
To explore the cell type-specific effects of PARP7 deficiency in the lung, we performed single-nucleus RNA sequencing (snRNA-seq) of lung from WT and Parp7-/- lung.
ORGANISM(S): Mus musculus 
2026-02-26 | GSE320001 | GEO
TranscriptomicsTranscriptional changes by PARP7 inhibitor in cancer cell lines
PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. PARP7 expression is increased by aromatic hydrocarbons and cellular stress, and the PARP7 gene is amplified in cancers, especially in those of the upper aerodigestive tract. PARP7 ...
ORGANISM(S): Homo sapiens 
2021-06-13 | GSE177494 | GEO
UnknownStructurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling.
Not available
S-EPMC9868104 | biostudies-literature
ProteomicsGenome-wide CRISPR screens and quantitative proteomics reveal remodelling of the aryl hydrocarbon receptor-controlled proteome through PARP7 activity
PARP7 is an enzyme that uses donor substrate NAD+ to attach a single ADP-ribose moiety onto proteins related to immunity, transcription, and cell growth and motility. Despite the importance of PARP7 in these processes, PARP7 signalling networks remain under-researched. Here, we used genome-wide CRIS...
ORGANISM(S): Homo sapiens (Human) 
2025-05-11 | PXD062520 | Pride
Screen Proteomics Ahr Mass spectrometry Parp Crispr Adp-ribosylation Aryl hydrocarbon receptor 
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