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ModelsHornberg2005 - MAPKsignalling
Hornberg2005 - MAPKsignalling Large model of the ERK signalling network. Results from this model were used to generate a simplified version of the network. This model is described in the article: Control of MAPK signalling: from complexity to what really matters. Hornberg JJ, Bind...
2024-09-02 | BIOMD0000000667 | BioModels
MetabolomicsComparative analysis of the adaptation of Staphylococcus aureus to internalization by different types of human non-professional phagocytic host cells (NMR assay)
Staphylococcus aureus is a human pathogen that can cause a wide range of diseases. Although formerly regarded as extracellular pathogen, it has been shown that S. aureus can also be internalized by host cells and persist within these cells. In the present study, we comparatively analyzed survival an...
2015-07-01 | MTBLS102 | MetaboLights
GenomicsPharmacological and genomic profiling identifies NFκB-targeted treatment strategies for mantle cell lymphoma
Mantle cell lymphoma (MCL) is an aggressive malignancy characterized by poor prognosis, underscoring the need for novel therapeutic strategies1. In this study, we employed large-scale pharmacological profiling of 16 pathway inhibitors across more than 100 hematological cell line models to identify n...
EGAS00001000622 | EGA
TranscriptomicsTranscription profiling of A. thaliana Col-0 wild type vs. myb11, myb12, myb111 triple mutant to identify targets of PFG
Comparison of Col-0 wt vs. Col myb11 myb12 myb111 triple mutant, screening for genes downregulated in the triple mutant; Screening for target genes of R2R3-MYB subgroup 7 transcription factors
ORGANISM(S): Arabidopsis thaliana 
2007-11-21 | E-ATMX-5 | biostudies-arrayexpress
ProteomicsIndependent human mesenchymal stromal cell-derived extracellular vesicle preparations differentially attenuate symptoms in an advanced murine Graft-versus-Host-Disease model
Extracellular vesicles (EVs) harvested from conditioned media of human mesenchymal stromal cells (MSCs) suppress acute inflammation in various disease models and promote regeneration of damaged tissues. Following successful treatment of an acute steroid-refractory Graft-versus-Host disease (GvHD) pa...
ORGANISM(S): Homo sapiens (Human) 
2023-06-12 | PXD032744 | Pride
Exosomes Graft-versus-host disease Mesenchymal stem cells Extracellular vesicles Heterogeneity Mesenchymal stromal cells 
ModelsHornberg2005_ERKcascade
SBML level 2 code generated for the JWS Online project by Jacky Snoep using PySCeS Run this model online at http://jjj.biochem.sun.ac.za To cite JWS Online please refer to: Olivier, B.G. and...
2024-09-02 | BIOMD0000000084 | BioModels
TranscriptomicsRNA-Seq data of Trpm7+/+ and Trpm7-/- embryonic stem cell clones
Partial exon deletion in Trpm7 gene was confirmed by lack of transcripts according to the RNA sequencing in two stem cell clones. For this mice were genetically modified by partial deletion of exon 2 and embryonic stem (ES) cell lines were generated. Isolated RNA of two ES clones was sequenced with ...
ORGANISM(S): Mus musculus 
2021-09-06 | E-MTAB-10877 | biostudies-arrayexpress
Genomicsena-DATASET-BCCA-06-12-2013-17:57:13:627-21 - samples
Complete set of bam files associated with study EGAS00001000622
EGAD00001000702 | EGA
TranscriptomicsInfluence of nalidixic acid on gene expression of Escherichia coli
The intention of this study is to analyse the effect of antibiotics on the gene expression of Escherichia coli. Shaking-flask cultivations of Escherichia coli K12GFP-UTL2 were carried out with a medium containing nalidixic acid. Cultures with antibiotic-free medium, which were run in an identical wa...
ORGANISM(S): Escherichia coli 
2010-05-25 | E-GEOD-8674 | biostudies-arrayexpress
TranscriptomicsTranslation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation
Macrophage activation by bacterial lipopolysaccharides (LPS) is induced through Toll-like receptor 4 (TLR4). The synthesis and activity of TLR4 downstream signalling molecules modulates the expression of pro- and anti-inflammatory cytokines. To address the impact of post-transcriptional regulation o...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-48463 | biostudies-arrayexpress
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