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TranscriptomicsTranscriptional profiling of an evolved polymorphism in E. coli
Microbial populations founded by a single clone and propagated under resource limitation can become polymorphic. We sought to understand how stable polymorphism arose in an Escherichia coli population that evolved for 765 generations under continuous glucose limitation. Apart from a 29 kb deletion i...
ORGANISM(S): Escherichia coli K-12 
2010-05-16 | E-GEOD-17276 | biostudies-arrayexpress
TranscriptomicsArray comparative genome hybridization of an evolved polymorphism in E. coli
Microbial populations founded by a single clone and propagated under resource limitation can become polymorphic. We sought to understand how stable polymorphism arose in an Escherichia coli population that evolved for 765 generations under continuous glucose limitation. Apart from a 29 kb deletion i...
ORGANISM(S): Escherichia coli K-12 
2010-05-15 | E-GEOD-17277 | biostudies-arrayexpress
TranscriptomicsSource-tracking fecal contamination by genomic analysis of Escherichia coli from human and animal hosts
The model prokaryote Escherichia coli can exist as a either a commensal or a pathogen in the gut of diverse mammalian hosts. These associations, coupled with its ease of cultivation and genetic variability, have made E. coli a popular indicator organism for tracking the origin of fecal water contam...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2013-03-01 | E-GEOD-21115 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human polymorphonuclear leukocytes (PMNs) from healthy individuals vs patients with X-linked chronic granulomatous disease
Polymorphonuclear leukocytes (PMNs) were obtained from healthy individuals (Healthy1, Healthy2, Healthy3, and Healthy4) or patients with X-linked chronic granulomatous disease (XCGD1, XCGD2, XCGD3, XCGD4, XCGD5, and XCGD6). The studies were performed in accordance with a protocol approved by the Ins...
ORGANISM(S): Homo sapiens 
2007-09-29 | E-GEOD-935 | biostudies-arrayexpress
UnknownStructural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain.
Not available
S-EPMC3090017 | biostudies-literature
TranscriptomicsNeuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal
Low energy states delay aging in multiple species, yet mechanisms coordinating energetics and longevity across tissues remain poorly defined. The conserved energy sensor AMP-activated protein kinase (AMPK) and its corresponding phosphatase calcineurin modulate longevity via the ‘CREB regulated trans...
ORGANISM(S): Caenorhabditis elegans 
2015-02-27 | E-GEOD-58931 | biostudies-arrayexpress
GenomicsMolecular Genetic Studies of Developmental Brain Disorders

Study 1
2R01-NS050375 (PI: DOBYNS, William B.)
The genetic basis of mid-hindbrain malformations
Our general goal for this project is to advance our understanding of human developmental disorders that involve the brainstem and cerebellum - brain structures derived from the embryoni...

phs000455.v1.p1 | EGA
TranscriptomicsTranscription profiling of human lpshigh and lpslow individuals to reveal interindividual variability in LPS responses
We used an unbiased approach to identify differences in gene expression that may account for the high degree of interindividual variability in inflammatory responses to LPS in the normal human population. We measured LPS-induced cytokine production ex vivo in whole blood from 102 healthy human subje...
ORGANISM(S): Homo sapiens 
2007-09-07 | E-GEOD-3491 | biostudies-arrayexpress
UnknownThe role of CDHR3 in susceptibility to otitis media.
Not available
S-EPMC8541908 | biostudies-literature
TranscriptomicsEGFR Mutation Promotes Glioblastoma Through Epigenome and Transcription Factor Network Remodeling
Epidermal Growth Factor Receptor (EGFR) gene amplification and mutations are the most common oncogenic events in Glioblastoma (GBM), but the mechanisms by which they promote aggressive tumor growth are not well understood. Here, through integrated epigenome and transcriptome analyses of cell lines, ...
ORGANISM(S): Homo sapiens 
2015-09-14 | E-GEOD-72468 | biostudies-arrayexpress
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