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TranscriptomicsLapatinib and retinoic acid combination treatment of SKBR3 breast cancer cells
SKBR3 cells, which bear both an HER2 and a RARA gene amplification, were treated for 12 or 48 hours with 100 nM retinoic acid, 100 nM lapatinib or the combination.The two drugs synergize and induce massive apoptosis. The aim is to find the molecular mechanism(s) of this synergism. Gene expression pr...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-MEXP-3192 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of blasts and normal cells from acute myeloid leukemia patients to study germinal copy number variants as potential disease risk factors
Except for the well-known association with Down syndrome, there is little information on the genetic factors predisposing to acute myeloid leukemia. Germinal gene copy-number variations may represent risk factors for the disease. To identify copy number variants present in both normal and leukemic ...
ORGANISM(S): Homo sapiens 
2015-10-01 | E-MTAB-2609 | biostudies-arrayexpress
TranscriptomicsSensitivity-resistance to the atypical retinoid ST1926 in NB4 acute myeloid leukemia cells
The two cell lines NB4 and NB4.437r, respectively sensitive and resistant to the cytotoxic action of the atypical retinoid ST1926 and CD437 were used to unveil the mechanism of action of these drugs.We compared their transcriptional profiles in conditions of exponential growth in basal medium by mic...
ORGANISM(S): Homo sapiens 
2013-01-08 | E-MEXP-3752 | biostudies-arrayexpress
TranscriptomicsA novel miRNA fingerprint inversely associated with breast cancer progression in SKBR3 cells challenged with all-trans retinoic acid and lapatinib
In SKBR3 cells, simultaneous targeting of RARM-kM-1 with all-trans retinoic acid (ATRA) and HER2 with lapatinib results in synergistic anti-tumor responses. SKBR3 cells were treated with vehicle (DMSO), lapatinib (100 nM), ATRA (100 nM) or lapatinib+ATRA for 36 hours and miRNA expression profile was...
ORGANISM(S): Homo sapiens 
2015-04-30 | E-MTAB-3097 | biostudies-arrayexpress
TranscriptomicsEffects of retinoids on estrogen-receptor-positive and -negative breast carcinoma cells: mRNA and miRNA profiling
This SuperSeries is composed of the following subset Series: GSE18390: Effects of retinoids on estrogen-receptor-positive and -negative breast carcinoma cells: mRNA profiling GSE18628: MicroRNA profiling shows different response to retinoids in estrogen-receptor positive and negative cells Refer to...
ORGANISM(S): Homo sapiens 
2010-05-21 | E-GEOD-18693 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling shows different response to retinoids in estrogen-receptor positive and negative cells
This Series reports results of miRNA profiling of estrogen-receptor-positive (MCF7) and estrogen-receptor-negative (MDA-MB-231) cells. Retinoic Acid (RA) induces mir-21 in MCF-7 but not in MDA-MB-231 cells. MCF-7 and MDA-MB-231 cells were treated (or not) with retinoic acid (RA) and grown for either...
ORGANISM(S): Homo sapiens 
2010-05-21 | E-GEOD-18628 | biostudies-arrayexpress
TranscriptomicsEffects of retinoids on estrogen-receptor-positive and -negative breast carcinoma cells: mRNA profiling
The overall study explores differential sensitivity of estrogen-receptor-positive and -negative breast carcinoma cells to retinoids via gene expression and microRNA profiling in MCF7 and MDA-MB-231 cells. This Series reports results of transcriptional profiling of breast carcinoma cell lines compari...
ORGANISM(S): Homo sapiens 
2010-05-21 | E-GEOD-18390 | biostudies-arrayexpress
TranscriptomicsAll trans-retinoic acid (ATRA) effect on triple negative (TNBC) and luminal (LumA/LumB) primary breast tumors
We performed whole genome gene expression microarrays on short-term cultures of mammary tumors deriving from diagnostic Tru-cut procedures of 16 patients in order to evaluate transcriptional response to the retinoid. Tissue slices were challenged with vehicle (DMSO) or ATRA 0.1åµm for 48 hours. The ...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-MTAB-3313 | biostudies-arrayexpress
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