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TranscriptomicsSLAM-seq analysis of mRNA half-lives in human CD8⁺ T cells during activation
SLAM-seq (thiol(SH)-linked alkylation for the metabolic sequencing of RNA) was applied to human primary CD8⁺ T cells subjected to in vitro activation with αCD3/αCD28 beads. To quantify mRNA half-lives and their dynamic changes during CD8⁺ T cell activation, we implemented a pulse-chase design with 2...
ORGANISM(S): Homo sapiens 
2025-10-15 | E-MTAB-15648 | biostudies-arrayexpress
TranscriptomicsTranscriptome of human HT1080 cells treated with purified typhoid toxin in the presence and absence of serum
Aim of the experiment: To examine changes in gene expression in HT1080 fibroblasts following treatment with purified recombinant wild-type typhoid toxin (WT-tox) from Salmonella Typhi relative to a mutant H160Q variant lacking DNase activity (HQ-tox), in the presence and absence of serum. The toxin ...
ORGANISM(S): Homo sapiens 
2025-06-01 | E-MTAB-15046 | biostudies-arrayexpress
UnknownSponge-derived matter is assimilated by coral holobionts.
Not available
S-EPMC10837432 | biostudies-literature
UnknownArginine methylation sites on SepIVA help balance elongation and septation in Mycobacterium smegmatis.
Not available
S-EPMC10023300 | biostudies-literature
UnknownFully synthetic macromolecular prodrug chemotherapeutics with EGFR targeting and controlled camptothecin release kinetics.
Not available
S-EPMC9847574 | biostudies-literature
UnknownNivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study.
Not available
S-EPMC5019749 | biostudies-literature
UnknownA Novel Immunocompetent Mouse Model for Testing Antifungal Drugs Against Invasive Candida albicans Infection.
Not available
S-EPMC7712810 | biostudies-literature
TranscriptomicsBiomolecular Condensate Coronas from Nanoparticle Intracellular Processing Are Transferred Between Cells Allowing Cytosolic and Nuclear Access
We describe ‘nanomaterial-biological hybrid complexes’ composed partly of an engineered nanoparticle core and formed partly by active processes within cells. Thus magnetic nanoparticles are internalized by cells, undergo active biomolecular deposition to form a new overlaid cell-derived corona layer...
ORGANISM(S): Homo sapiens 
2026-04-16 | E-MTAB-16398 | biostudies-arrayexpress
UnknownPhase 1 study of the pan-RAF inhibitor tovorafenib in patients with advanced solid tumors followed by dose expansion in patients with metastatic melanoma.
Not available
S-EPMC10261210 | biostudies-literature
UnknownTargeting the DNA repair pathway in Ewing sarcoma.
Not available
S-EPMC4386669 | biostudies-literature
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