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ProteomicsThe human iRHOM2 interactome upon KRAS expression
ADAM17 is a cell surface protease that controls the release of the ectodomains of signalling proteins including EGFR ligands and the primary inflammatory cytokine TNF. Reflecting this important role in signalling, dysregulated ADAM17 activity is linked to many human diseases including immunodeficien...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD063983 | Pride
Protease Signalling Rhomboid 
UnknownTissue specificity of in vitro drug sensitivity.
Not available
S-EPMC6381764 | biostudies-literature
TranscriptomicsCirculating insulin-like growth factor (IGF)-1 Regulates Hippocampal IGF-1 Levels and Brain Gene Expression During Adolescence
This study, using a growth hormone (GH)-deficient dwarf animal model and peripheral GH replacement, investigated the effects of circulating IGF-1 during adolescence on IGF-1 levels in the brain. Our results demonstrated that hippocampal IGF-1 protein concentrations during adolescence are highly regu...
ORGANISM(S): Rattus norvegicus 
2011-07-20 | E-GEOD-29512 | biostudies-arrayexpress
ProteomicsMineral-bound ostrich eggshell peptides survive for up to 3.8 Ma in equatorial Africa
Claims for exceptional preservation of biomolecules in the fossil record are contested. Here we demonstrate the role of surface stabilisation in significantly prolonging protein sequence survival to ~3.8 million years. The intracrystalline environment of calcite ostrich (Struthionidae) eggshell enca...
ORGANISM(S): Struthio camelus (Ostrich) 
2018-07-16 | PXD003786 | Pride
Molecular dynamics Mineral binding Proteomics Struthiocalcin Eggshell Lc-ms/ms 
UnknownBacterial rhomboid proteases mediate quality control of orphan membrane proteins
Not available
S-SCDT-EMBOJ-2019-102922 | biostudies-other
TranscriptomicsAdvancing systemic toxicity risk assessment: Evaluation of a NAM-based toolbox approach
High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with multiple compounds as part of a study to generate a toolbox and workflow for non-animal safety assessments. The data generated here was produced as one part of a toolb...
ORGANISM(S): Homo sapiens 
2025-09-15 | E-MTAB-15266 | biostudies-arrayexpress
GenomicsCohort-Based Genome-Wide Association Study of Glioma (GliomaScan)

We conducted a new independent GWAS of adult glioma using 1,856 cases and 4,955 controls from 14 cohort studies belonging to the Cohort Consortium, 3 case-control studies, and 1 population-based case only study. Cases were newly diagnosed glioma [ICDO-3 codes 9380-9480 or equivalent], and control...

phs000652.v1.p1 | EGA
TranscriptomicsAre Non-animal Systemic Safety Assessments Protective: A Toolbox and Workflow
High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with multiple compounds as part of a study to generate a toolbox and workflow for non-animal safety assessments. The data generated here was produced as one part of a toolb...
ORGANISM(S): Homo sapiens 
2025-09-15 | E-MTAB-15258 | biostudies-arrayexpress
TranscriptomicsAn Advancement in Developmental and Reproductive Toxicity (DART) Risk Assessment: Evaluation of a Bioactivity and Exposure-Based NAM Toolbox
High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with multiple compounds as part of a study to generate a toolbox and workflow for non-animal safety assessments. The data generated here was produced as one part of a toolb...
ORGANISM(S): Homo sapiens 
2025-09-15 | E-MTAB-15274 | biostudies-arrayexpress
GenomicsWTCCC2 Visceral Leishmaniasis (VL) samples
A WTCCC2 project genome-wide association study for visceral leishmaniasis (VL) in individuals from India, Brazil and Sudan, genotyped on the custom Illumina 670k array. The WTCCC2 analysis of the Brazilian and Indian samples is described in Fakiola et al. [Nat Genet. 2013 Feb;45(2):208-13]. It shoul...
EGAS00001000773 | EGA
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