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TranscriptomicsEmbryonic exposure to 10 µg/L lead results in female-specific expression changes in genes associated with nervous system development and function and Alzheimer’s disease in aged adult zebrafish brain
A developmental lead (Pb) exposure has been proposed as an environmental risk factor for adult neurodegenerative diseases including Alzheimer’s disease (AD). Recent animal studies showed pathological characteristics of AD in adults with a developmental Pb exposure, but additional studies are neede...
ORGANISM(S): Danio rerio 
2016-02-08 | E-GEOD-74037 | biostudies-arrayexpress
TranscriptomicsEmbryonic exposure to 10 µg/L lead results in male-specific expression changes in genes associated with nervous system development and function and Alzheimer’s disease in aged adult zebrafish brain
A developmental lead (Pb) exposure has been proposed as an environmental risk factor for adult neurodegenerative diseases including Alzheimer’s disease (AD). Recent animal studies showed pathological characteristics of AD in adults with a developmental Pb exposure, but additional studies are neede...
ORGANISM(S): Danio rerio 
2016-02-08 | E-GEOD-74038 | biostudies-arrayexpress
ProteomicsEnzymatic activation of the nitrogen atom in peptide bonds
Abstract The peptide bond is the defining feature of proteins, it co ntrols their structure by enforcing planarity and governs their chemistry by abolishing nucleophili city. This behaviour results from the delocalisation of the lone pair of electrons on the ni...
ORGANISM(S): Escherichia coli 
2020-03-20 | PXD005934 | Pride
Amide chemistry and biochemistry Methylation Enzyme catalysis 
TranscriptomicsRNA-seq of human GM12878 and JURKAT cells treated with aphidicolin and Sendai virus against untreated controls
Human B lympoblastoid cells, GM12878 and human T cells, JURKAT, were treated with aphidicolin (to arrest cells at G1/S boundary) for 24h, the last 12h with the Sendai virus. The experiment was performed in three biological replicates. Gene expression changes upon aphidicolin and or infection betwee...
ORGANISM(S): Homo sapiens 
2025-08-27 | E-MTAB-13340 | biostudies-arrayexpress
MetabolomicsSponge exhalent seawater contains a unique chemical profile of dissolved organic matter
Sponges are efficient filter feeders, removing significant portions of particulate and dissolved organic matter (POM, DOM) from the water column. While the assimilation and respiration of POM and DOM by sponges and their abundant microbial symbiont communities have received much attention, there is ...
2016-02-01 | MTBLS281 | MetaboLights
TranscriptomicsMicroarray analysis of macrophages derived from mouse bone marrow cells with or without metformin treatment
In this study, we investigated the effects of metformin on the differentiation of bone marrow-derived macrophages (BMDMs) and their potential role in cancer immunity. BMDMs were generated from bone marrow cells extracted from C57BL/6N mice and differentiated in the presence or absence of metformin. ...
ORGANISM(S): Mus musculus 
2025-06-13 | E-MTAB-14199 | biostudies-arrayexpress
TranscriptomicsA Gene Expression Atlas of the Domestic Pig
A Gene Expression Atlas of the Domestic Pig
ORGANISM(S): Sus scrofa 
2012-09-01 | E-MTAB-1183 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD8 naive (TN), central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells
Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naïve (TN), central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells using gene expression microarrays and phospho-protein-specific i...
ORGANISM(S): Homo sapiens 
2005-01-01 | E-TABM-40 | biostudies-arrayexpress
TranscriptomicsRNA-seq of primary human brain endothelial cells cultured on hydrogel substrates and exposed to static or fluid shear stress conditions
This study was designed to investigate the consequences of substrate stiffness on primary brain microvascular endothelial cells (BMECs) in the presence of fluid shear stress (FSS) of 1.7 dyne/cm2. We utilized two gelatin (GEL) substrates of different w/v% (6.5% and 15%) that were crosslinked with m...
ORGANISM(S): Homo sapiens 
2025-12-01 | E-MTAB-15011 | biostudies-arrayexpress
TranscriptomicsscRNA-seq from Trex1 KO in heart
Single-cell RNA-seq data for Trex1 WT and KO mice from the heart. Used for manuscript in submission at Science Advances.
ORGANISM(S): Mus musculus 
2026-03-25 | E-MTAB-16525 | biostudies-arrayexpress
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