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TranscriptomicsTranscription profiling of human CD8 naive (TN), central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells
Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naïve (TN), central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells using gene expression microarrays and phospho-protein-specific i...
ORGANISM(S): Homo sapiens 
2005-01-01 | E-TABM-40 | biostudies-arrayexpress
TranscriptomicsGenome-wide transcriptional analyses of islet-specific CD4+ T cells identify Idd9 genes controlling diabetogenic T cell function
Analysis of gene expression levels in ex-vivo and p79-stimulated splenic CD4+ T cells. Total RNA obtained from ex-vivo CD4+TCRVβ4+ T cells from BDC-Idd9 mice compared to BDC mice and p79-stimulated CD4+TCRVβ4+ T cells from BDC-Idd9 mice compared to BDC mice.
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-64674 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of HIV-specific CD8 T cells from controllers and progressors
CD8+ T cells in chronic viral infections like HIV develop functional defects such as loss of IL-2 secretion and decreased proliferative potential that are collectively termed exhaustion1. Exhausted T cells express increased levels of multiple inhibitory receptors, such as Programmed Death 1 (PD-1)...
ORGANISM(S): Homo sapiens 
2010-10-03 | E-GEOD-24081 | biostudies-arrayexpress
TranscriptomicsscRNA-seq characterisation of in vitro-generated CD8+ exhausted human T cells
scRNA-seq was performed to characterise an in vitro model of T cell exhaustion. CD8+ T cells from two donors underwent chronic stimulation to induce exhaustion and samples were collected from multiple points across the protocol to examine the subsets and transcriptional signatures present.
ORGANISM(S): Homo sapiens 
2026-05-31 | E-MTAB-15435 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of HIV-specific CD8 T cells from controllers and progressors and Jurkat cells with or without PD-1 ligation
This SuperSeries is composed of the following subset Series: GSE24026: Comparison of gene expression profiles of Jurkat cells with or without PD-1 ligation GSE24081: Comparison of gene expression profiles of HIV-specific CD8 T cells from controllers and progressors Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-10-03 | E-GEOD-24082 | biostudies-arrayexpress
TranscriptomicsGLORI mapping of m⁶A sites in human primary CD8⁺ T cells under activation and METTL3 inhibition
Glyoxal and nitrite-mediated deamination of unmethylated adenosines (GLORI) was applied to human primary CD8⁺ T cells subjected to in vitro activation with αCD3/αCD28 beads. To identify N⁶-methyladenosine (m⁶A) sites at single-nucleotide resolution and to test their dependence on METTL3, we generate...
ORGANISM(S): Homo sapiens 
2025-10-15 | E-MTAB-15649 | biostudies-arrayexpress
TranscriptomicsSLAM-seq analysis of mRNA half-lives in human CD8⁺ T cells during activation
SLAM-seq (thiol(SH)-linked alkylation for the metabolic sequencing of RNA) was applied to human primary CD8⁺ T cells subjected to in vitro activation with αCD3/αCD28 beads. To quantify mRNA half-lives and their dynamic changes during CD8⁺ T cell activation, we implemented a pulse-chase design with 2...
ORGANISM(S): Homo sapiens 
2025-10-15 | E-MTAB-15648 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse T regulatory and T effector cells isolated from the pancreatic lesion of 3-4 wk old BDC2.5 tg NOD mice
Comparison of gene expression between T regulatory and T effector cells isolated from the pancreatic lesion of 3-4 wk old BDC2.5 tg NOD mice. WARNING: These data files were obtained from GSM155557.CEL and GSM23405.CEL may be identical.
ORGANISM(S): Mus musculus 
2007-09-29 | E-GEOD-1419 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of BrO, DMGO and GD2 CAR T cells
Diffuse midline glioma (DMG) is a lethal pediatric brain cancer with limited treatment options. We developed a human brainstem organoid model to study H3.3K27M-driven DMG, enabling formation of patient-like tumors with molecular heterogeneity. To characterize this model, we performed a time-course t...
ORGANISM(S): Homo sapiens 
2025-08-28 | E-MTAB-15147 | biostudies-arrayexpress
TranscriptomicsPrimary and secondary CD8 T cells during acute and chronic LCMV infection
Understanding the response of memory CD8 T cells to persistent antigen re-stimulation and the role of CD4 T cell help is critical to the design of successful vaccines for chronic diseases. However, studies comparing the protective abilities and qualities of memory and naïve cells have been mostly pe...
ORGANISM(S): Mus musculus 
2011-08-22 | E-GEOD-30962 | biostudies-arrayexpress
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