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ProteomicsBottom-up proteomics of EZH2 mutants in isogenic cells
The Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit (EZH2) is an essential epigenetic modifier able to methylate lysine 27 on histone H3 (H3K27) to induce chromatin compaction, protein complex recruitment and ultimately transcriptional repression. Hematologic malignancies, including Diffus...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042875 | Pride
Lymphoma Epigenetics Leukemia Mutations Ezh2 
ProteomicsHistone PTM profiling analysis of EZH2 mutants in isogenic cells
The Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit (EZH2) is an essential epigenetic modifier able to methylate lysine 27 on histone H3 (H3K27) to induce chromatin compaction, protein complex recruitment and ultimately transcriptional repression. Hematologic malignancies, including Diffus...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042953 | Pride
Lymphoma Epigenetics Leukemia Ezh2 
ProteomicsOptimization of Proteomics Sample Preparation for Forensic Analysis of Skin Samples
We present an efficient protein extraction and in-solution enzymatic digestion protocol optimized for mass spectrometry-based proteomics studies of human skin samples.
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD022720 | Pride
Proteomics  sample preparation  protein extraction  trypsin digestion  surfactants  human forensics 
ProteomicsPROTEOMIC ANALYSIS OF THE UMBILICAL CORD IN FETAL GROWTH RESTRICTION AND PREECLAMPSIA
Fetal growth restriction (FGR) is associated with adverse perinatal outcomes. Pre-eclampsia (PreE) increases the associated perinatal morbidity and mortality. The structure of the umbilical cord in the setting of FGR and PreE has yet to be determined. This study aimed to examine chan...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-15 | MSV000087051 | MassIVE
UnknownDerivation and Validation of Genome-Wide Polygenic Score for Ischemic Heart Failure.
Not available
S-EPMC8751935 | biostudies-literature
TranscriptomicsIn vivo NCL-targeting affects breast cancer aggressiveness through miRNA regulation [Affymetrix]
Numerous studies have described the altered expression and the causal role of miRNAs in human cancer. However, to date efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here, we find that Nucleolin (NCL), a major nucleolar protein, post-transcriptionally r...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-41972 | biostudies-arrayexpress
UnknownRetrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City.
Not available
S-EPMC7702220 | biostudies-literature
UnknownDelayed Processing of Secretin-Induced Pancreas Fluid Influences the Quality and Integrity of Proteins and Nucleic Acids.
Not available
S-EPMC7883383 | biostudies-literature
UnknownMachine Learning to Predict Mortality and Critical Events in a Cohort of Patients With COVID-19 in New York City: Model Development and Validation.
Not available
S-EPMC7652593 | biostudies-literature
UnknownZika-specific neutralizing antibodies targeting inter-dimer envelope epitopes.
Not available
S-EPMC10775418 | biostudies-literature
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