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TranscriptomicsGene expression analysis of SDH-deficient immortalized kidney epithelial cells
Succinate dehydrogenase (SDH) is a mitochondrial protein complex responsible for the oxidation of succinate to fumarate in the tricarboxylic acid cycle. Loss-of-function mutations in any of the SDH genes are associated with susceptibility to develop neu-roendrocrine neoplasms and renal cell carcinom...
ORGANISM(S): Mus musculus 
2016-01-22 | E-MTAB-4349 | biostudies-arrayexpress
ProteomicsFOXA2 controls the anti-oxidant response in FH-deficient cells independent of NRF2
Hereditary Leiomyomatosis and renal cell cancer (HLRCC) is caused by germline mutations of fumarate hydratase (FH) and subsequence accumulation of fumarate. Fumarate is known to activate the anti-oxidant response by KEAP1 succination and nuclear translocation of the transcription factor NRF2. The ac...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-20 | PXD034141 | Pride
Anti-oxidant response Nrf2 Fumarate hydratase Foxa2 
ProteomicsTumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma
Human isotopic tracer studies are fast becoming the gold standard model to study cancer metabolism in vivo. Analysed tissues are typically retrieved after surgical resection, which exposes them to a variable extent of warm ischaemia. Although standardised protocols are emerging, the effects of sampl...
ORGANISM(S): Homo sapiens (Human) 
2025-08-30 | PXD054588 | Pride
13c-glucose Metabolism Human isotopic tracers Clear cell renal cell carcinoma (ccrcc) In vivo Kidney cancer Ischaemia 
TranscriptomicsComparison of KrasG12D/WT;p53Fx/Fx and KrasG12D/G12D;p53Fx/Fx MEFs
Microarray expression data generated to compare the biological impact of KrasG12D allelic duplication in p53null mouse embryonic fibroblasts (MEFs). The RAS/MAPK-signalling pathway is frequently deregulated in non-small cell lung cancer (NSCLC), often through activating mutations in KRAS. Mouse mode...
ORGANISM(S): Mus musculus 
2016-02-24 | E-GEOD-75871 | biostudies-arrayexpress
MetabolomicsDissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by loss-of-function mutations in PKD1 or PKD2. Increased glycolysis is a prominent feature of the disease, but how it impacts on other metabolic pathways is unknown. Here, we present an analysis of mouse Pkd1 mutant ce...
2019-06-07 | MTBLS677 | MetaboLights
MetabolomicsDiversity in DNA: Identification of methylated deoxyadenosines in higher eukaryotes
Since the discovery that cytosine deoxynucleotides could be methylated (dC5m), not much is known in higher eukaryotes about modifications affecting other deoxynucleotides. Here, we now report that we detected N-6-methyl-deoxyadenosine (dA6m) not only in frog DNA, but also in other species including ...
2015-11-16 | MTBLS276 | MetaboLights
GenomicsH3K27ac ChIP-seq of Fh1-WT, Fh1-KO and Fh1-rec cells
To identify active regulatory regions of the genome, we performed H3K27ac ChIP-seq.
ORGANISM(S): Mus musculus 
2022-09-01 | E-MTAB-11790 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Fh1-WT and Fh1-KO treated with either siNT or siFoxa2
To identify the transcriptional targets of Foxa2, we treated Fh1-WT or Fh1-KO cells with either siNT or siFoxa2 and subsequent RNA-sequencing.
ORGANISM(S): Mus musculus 
2022-09-01 | E-MTAB-11782 | biostudies-arrayexpress
GenomicsChIP-seq of NRF2 in Fh1-KO cells
To identify the genomic location of FOXA2 in and Fh1-KO cells.
ORGANISM(S): Mus musculus 
2023-06-12 | E-MTAB-13042 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse kidney epithelial cells
Fumarate hydratase (FH) is the enzyme in the Krebs cycle, which transforms fumarate to malate. Loss of fumarate hyrdragase leads to hereditary leiomyomatosis and renal cell cancer (HLRCC). The biallelic inactivation has been highly accumulated in FH-deficient cells and is considered a major pro-onco...
ORGANISM(S): Mus musculus 
2014-11-19 | E-GEOD-63438 | biostudies-arrayexpress
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