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MetabolomicsSuccinate accumulation drives ischaemia-reperfusion injury during organ transplantation
During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient. Despite its widespread use, our understanding of the m...
2019-09-20 | MTBLS1085 | MetaboLights
TranscriptomicsTranscription profiling of rat heart after ischaemia reperfusion injury and then treatment with saline, urocortin I, urocortin II or tempol
The transcriptional effects of urocortin I, urocortin II and tempol were compared to saline treatment in a rat model of in vivo coronary artery occlusion model of ischaemia/reperfusion injury of 25 min ischaemia and 2 hr reperfusion.
The treatment groups were as follows (i) sham operation or LAD...
ORGANISM(S): Rattus norvegicus 
2009-03-25 | E-MEXP-2098 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pig postischaemic restituted intestinal mucosa after further ischaemic insult
Background: Restitution of the surface epithelium is a critical healing process early after ischaemic injury of the gut mucosa. Repeated episodes of intestinal ischaemia occur in many critically ill patients. This study evaluates the resistance of postischaemic restituted intestinal mucosa to a furt...
ORGANISM(S): Sus scrofa 
2007-09-20 | E-MEXP-978 | biostudies-arrayexpress
TranscriptomicsExpression data from total knee arthroplasty patients
Ischaemic preconditioning is a method of protecting tissue against ischaemia-reperfusion injury. It is an innate protective mechanism that increases a tissue's tolerance to prolonged ischaemia when it is first subjected to short burst of ischaemia and reperfusion. It is thought to provide this prot...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-21164 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hearts from young (2-4 month) and moderately aged (16-18 month) C57/Bl6 male mice subjected to i) 20 min global ischaemia, 60 min reperfusion or ii) 80 min aerobic perfusion/normoxia
Hearts from young (2-4 month) and moderately aged (16-18 month) C57/Bl6 male mice were subjected to i) 20 min global ischaemia, 60 min reperfusion or ii) 80 min aerobic perfusion/normoxia.
ORGANISM(S): Mus musculus 
2005-12-31 | E-MEXP-496 | biostudies-arrayexpress
TranscriptomicsExpression data from an ex vivo ischaemia reperfusion model of renal deceased by cardiac death (DCD) donation in rat
In DCD organ donation one of the significant problems for the organ is the inflammatory response due to ischaemia reperfusion injury caused by warm ischaemia prior to retrieval followed by warm reoxygenation upon transplantation. We developed a model where a DCD kidney was retrieved and preserved us...
ORGANISM(S): Rattus norvegicus 
2012-03-22 | E-GEOD-36671 | biostudies-arrayexpress
ProteomicsDiabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischaemia
The bioactive lipid intermediate palmitoyl CoA (PCoA) can inhibit mitochondrial ADP/ATP transport, though the physiological relevance of this regulation remains unclear. We questioned whether myocardial ischaemia was a pathological setting in which PCoA regulation of ADP/ATP transport would be bene...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-17 | PXD024500 | Pride
Pcoa Ischemia 
TranscriptomicsExpression data from an ex vivo ischaemia reperfusion model of renal deceased by cardiac death (DCD) donation in rat
In DCD organ donation one of the significant problems for the organ is the inflammatory response due to ischaemia reperfusion injury caused by warm ischaemia prior to retrieval followed by warm reoxygenation upon transplantation. We developed a model where a DCD kidney was retrieved and preserved us...
ORGANISM(S): Rattus norvegicus 
2012-03-22 | GSE36671 | GEO
GenomicsRNA-seq of bone marrow derived macrophages from mice undergoing hind-limb ischaemia surgery versus controls with or without lipopolysaccharide stimulation
RNA-seq of bone marrow derived macrophages from mice undergoing hind-limb ischaemia surgery versus controls with or without lipopolysaccharide stimulation
PRJEB98085 | ENA
ProteomicsFTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregulating ACSL4 and TFRC
Older livers are more prone to hepatic ischaemia/reperfusion injury (HIRI), which severely limits their utilization in liver transplantation (LT); however, the potential mechanism remains unclear. Here, we demonstrated older livers exhibit a higher degree of ferroptosis during HIRI. Inhibiting ferro...
ORGANISM(S): Mus Musculus 
PXD051387 |
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