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ProteomicsStructural Basis of Kinesin-1 Autoinhibition and Its Control of Microtubule-Based Motility
Kinesin-1 is the first identified microtubule-based motor protein that drives anterograde intracellular transport of diverse cargoes in eukaryotic cells. Defects in kinesin-1 activity have been implicated in various human neurological disorders and intracellular pathogens such as bacteria and viruse...
ORGANISM(S): Escherichia coli 
2026-06-03 | PXD073177 | Pride
Kinesin-1 Structure Kinesin Kif5b Plus-end directed Microtubule motor Cryo-em Motor protein 
ProteomicsChaperone Dependency during Primary Protein Biogenesis Does Not Correlate with Chaperone Dependency during in vitro Refolding
Many proteins require molecular chaperones to fold into their functional native forms. Previously we used limited proteolysis mass-spectrometry (LiP-MS) to find that ca. 40% of the E. coli proteome do not efficiently refold spontaneously following dilution from denaturation, a frequency that drops t...
ORGANISM(S): Escherichia coli 
2025-09-22 | PXD064568 | Pride
Chaperones  protein folding  dnak  trigger factor  co-translational folding  structural proteomics 
ProteomicsProgress Toward Proteome-Wide Photo-Crosslinking to Enable Residue-Level Visualization of Protein Structure and Networks in vivo
Crosslinking mass spectrometry (XL-MS) is emerging as a method at the crossroads of structural and cellular biology, uniquely capable of identifying protein-protein interactions with residue-level resolution and on the proteome-wide scale. With the development of crosslinkers that can form linkages ...
ORGANISM(S): Escherichia coli 
2023-06-27 | PXD041148 | Pride
Diazirines Cleavable cross-linkers Proteomics Quinary interactions Nhs-carbamate. Photo-crosslinking Protein interaction networks 
ProteomicsCryo-EM structures of the Plant Augmin reveal its intertwined coiled-coil assembly, antiparallel dimerization and NEDD1 binding mechanisms
Microtubule (MT) branch nucleation is fundamental for building parallel MT networks in eukaryotic cells. In plants and metazoans, MT branch nucleation requires Augmin and NEDD1 proteins which bind along MTs and then recruit and activate the gamma-tubulin ring complex (g-TuRC). Augmin is a fork-shap...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-10-31 | PXD065516 | Pride
Microtubule Augmin G-turc Xl-ms Nedd1 
ProteomicsCatechol-O-Methyltransferase connects dopamine homeostasis to redox signaling, metal homeostasis and protein folding in schizophrenia
Dysregulation of dopamine (DA) signaling and redox homeostasis contributes to multiple neuropsychiatric and neurodegenerative disorders. Polymorphisms that influence the activity of catechol‑O‑methyltransferase (COMT), an enzyme critical for degrading dopamine (DA) in the dorsolateral prefrontal cor...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-28 | PXD075030 | Pride
Limited proteolysis Thermo-fisher ascend Rat Pc12 cells 
UnknownCanadian Surgery Forum.
Not available
S-EPMC3432251 | biostudies-literature
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