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ProteomicsA lncRNA from the FTO locus acts as an inhibitor of the m6A writer complex and p53 tumor suppression signaling
control RNA and FTO-IT1 RNA and their interacting proteins were pulled down by biotin-streptavidin beads to see the interacting protein of FTO-IT1 RNA.
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD041053 | Pride
Fto-it1 Prostate cancer 
UnknownLncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO-mediated N6-methyladenosine modification on GLUT1 and PKM2.
Not available
S-EPMC10578010 | biostudies-literature
TranscriptomicsA lncRNA from the FTO locus acts as an inhibitor of mRNA m6A methylation and p53 tumor suppression
The FTO gene locus has been linked to cancer and obesity through encoded N6-methyladenosine (m6A) demethylase FTO or inherited genomic variants (e.g. intronic single-nucleotide polymorphisms). Here we demonstrate that FTO-IT1, a long noncoding RNA (lncRNA) transcribed from a FTO gene intron, is upre...
ORGANISM(S): Homo sapiens 
2023-07-08 | GSE212043 | GEO
TranscriptomicsN6-methyladenosine modification is essential for prostate cancer cells
N6-methyladenosine (m6A) modification of messenger RNAs (mRNAs) is a pivotal mechanism controlling mRNA fate in cells. RNA m6A modification is regulated by the functional balance between methyltransferases and demethylases. Here we demonstrated that FTO-IT1 enhancer RNA (eRNA), a long non-coding RNA...
ORGANISM(S): Homo sapiens 
2023-07-09 | GSE189465 | GEO
UnknownA lncRNA from the FTO locus acts as a suppressor of the m6A writer complex and p53 tumor suppression signaling.
Not available
S-EPMC10427207 | biostudies-literature
GenomicsA lncRNA from the FTO locus acts as an inhibitor of mRNA m6A methylation and p53 tumor suppression
A lncRNA from the FTO locus acts as an inhibitor of mRNA m6A methylation and p53 tumor suppression
PRJNA873688 | ENA
GenomicsN6-methyladenosine modification is essential for prostate cancer cells
N6-methyladenosine modification is essential for prostate cancer cells
PRJNA783056 | ENA
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