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TranscriptomicsNon-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2
A synthetic analog of sphingosine named FTY720 (Fingolimod), phosphorylated by sphingosine kinase-2, interacts with sphingosine-1-phosphate (S1P) receptors expressed on various cells. FTY720 suppresses the disease activity of multiple sclerosis (MS) chiefly by inhibiting S1P-dependent egress of auto...
ORGANISM(S): Homo sapiens 
2011-04-16 | E-GEOD-28642 | biostudies-arrayexpress
TranscriptomicsHippocampal expression data from FTY720- and vehicle-treated SCID mice following fear consolidation testing
FTY720/Fingolimod, an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. Here we show that FTY720 enters the nucleus where it is phosphorylated by sphingosine kinase 2 (SphK...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-57015 | biostudies-arrayexpress
ProteomicsEffects of FTY720 on phospho-proteome of leukemic cells
: FTY720 (Fingolimod) is an immunosuppressive drug approved by FDA for Multiple Sclerosis (MS), that has gained attention as anti-cancer drug, thanks to its ability to disrupt the binding between the onco-protein SET and the tumor- suppressor phosphatase PP2A. We investigated FTY720 induced phospho...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038288 | Pride
Fty720 Pp2a Phosphoproteomics Set Fingolimod Aml Lc-ms/ms 
TranscriptomicsExpression analysis of Kasumi-1 cells treated with or without FTY720
The clinical outcomes of M2 subtype Acute Myeloid Leukemia (AML-M2) with t(8;21) are poor. Here we report that FTY720 (Fingolimod), a sphingosine analogue and an FDA approved drug for treatment of multiple sclerosis, showed great antitumorigenic activity against Kasumi-1 cell line, xenograft mouse m...
ORGANISM(S): Homo sapiens 
2014-04-30 | E-GEOD-55772 | biostudies-arrayexpress
GenomicsEffects of FTY720/IFNb on astrocytes
Combinatorial FTY720/IFNb induces protective factors in astrocytes
PRJEB48316 | ENA
UnknownFTY720-derivatives do not induce FTY720-like lymphopenia.
Not available
S-EPMC7959251 | biostudies-literature
UnknownPulmonary endothelial cell barrier enhancement by novel FTY720 analogs: methoxy-FTY720, fluoro-FTY720, and β-glucuronide-FTY720.
Not available
S-EPMC4655823 | biostudies-literature
TranscriptomicsFTY720 (fingolimod) regulates key target genes essential for inflammation in microglial cells
Although microglial have an essential role in host defense in the brain, the abnormal activation of microglia can lead to devastating outcomes, such as neuroinflammation and neurodegeneration. Emerging evidence increasingly supports that FTY720 (fingolimod), an FDA-approved drug has beneficial effec...
ORGANISM(S): Mus musculus 
2017-11-27 | GSE90932 | GEO
TranscriptomicsNon-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2
A synthetic analog of sphingosine named FTY720 (Fingolimod), phosphorylated by sphingosine kinase-2, interacts with sphingosine-1-phosphate (S1P) receptors expressed on various cells. FTY720 suppresses the disease activity of multiple sclerosis (MS) chiefly by inhibiting S1P-dependent egress of auto...
ORGANISM(S): Homo sapiens 
2011-04-16 | GSE28642 | GEO
TranscriptomicsExpression analysis of Kasumi-1 cells treated with or without FTY720
The clinical outcomes of M2 subtype Acute Myeloid Leukemia (AML-M2) with t(8;21) are poor. Here we report that FTY720 (Fingolimod), a sphingosine analogue and an FDA approved drug for treatment of multiple sclerosis, showed great antitumorigenic activity against Kasumi-1 cell line, xenograft mouse m...
ORGANISM(S): Homo sapiens 
2014-04-30 | GSE55772 | GEO
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