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TranscriptomicsTranscription profiling of QUB HCT116 sensitive and resistant colorectal cancer time series
HCT116 parental, HCT116 5-FU resistant and HCT116 oxaliplatin resistant cells have been transiently treated with with their respective drug (5-FU or oxaliplatin) for 0, 6 12 or 24h in 3 independent experiments.
ORGANISM(S): Homo sapiens 
2006-01-01 | E-MEXP-390 | biostudies-arrayexpress
TranscriptomicsZebrafish liver transcriptome in response to chronic treatment with environmentally relevant 5-FU
The fluoropyrimidine 5-fluorouracil (5-FU) is an antimetabolite that exerts its anticancer effects through inhibition of DNA synthesis and replication by inhibiting thymidylate synthase, and by incorporation of its metabolites into RNA and DNA. 5-FU is used in most of the currently applied regimens ...
ORGANISM(S): Danio rerio 
2015-04-23 | E-GEOD-63039 | biostudies-arrayexpress
ProteomicsQuantitative phosphoproteomics of chronic sunitinib treated renal cell carcinoma 786-O cells with GPR30 agonist G-1
In this project, we generated chronic sunitinib-treated 786-O cell, a renal cell carcinoma cell line. In order to investigate the possible effect of GPR30 agonist, G-1, on the growth-inhibtion related signaling pathways, we treated either parental both parental and chronic sunitinib-treated 786-O ce...
ORGANISM(S): Homo sapiens (Human) 
2021-04-28 | PXD021254 | Pride
Renal cell carcinoma Sunitinib Gpr30 
Genomics5- FU treated organoids
5-Fluorouracil (5-FU) is a chemotherapeutic drug component that is commonly used for the treatment of solid cancers. The anticancer properties of 5-FU have been attributed to interference with nucleotide synthesis and through direct incorporation into the DNA as being a pyrimidine analog. As both m...
EGAS00001003592 | EGA
UnknownReversing uL3-mediated chemoresistance through synergistic combination of 5-FU and G-quadruplex ligands.
Not available
S-EPMC12661320 | biostudies-literature
UnknownEukaryotic translation initiation factor 3 subunit G (EIF3G) resensitized HCT116/5-Fu to 5-fluorouracil (5-Fu) via inhibition of MRP and MDR1.
Not available
S-EPMC6126502 | biostudies-literature
UnknownSoluble HLA-G expression levels and HLA-G/irinotecan association in metastatic colorectal cancer treated with irinotecan-based strategy.
Not available
S-EPMC7260212 | biostudies-literature
GenomicsRNA serves as direct thermo and potassium sensors via spliceswitch formed by G-quadruplex in mammals
RNA serves as direct thermo and potassium sensors via spliceswitch formed by G-quadruplex in mammals
PRJNA1092057 | ENA
UnknownG-Protein-coupled Estrogen Receptor 1 Agonist G-1 Perturbs Sunitinib Resistance-related Phosphoproteomic Signatures in Renal Cell Carcinoma.
Not available
S-EPMC8126328 | biostudies-literature
TranscriptomicsGene expression patterns induced by 5-Fluorouracil in breast cancer cell lines
We have compared the changes in cell cycle and cell death parameters induced by 2 different concentrations of 5-FU (IC50 and IC80) in the breast adenocarcinoma cell line MCF7. G1/S cell cycle arrest was associated with both concentrations, whereas cell death was mainly induced after IC80 5-FU. These...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-2584 | biostudies-arrayexpress
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