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UnknownIntegrating network pharmacology and experimental validation to uncover the synergistic effects of Huangqi ()-Ezhu () with 5-fluorouracil in colorectal cancer models.
Not available
S-EPMC11955770 | biostudies-literature
GenomicsThe Mediator complex subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination
The Mediator complex orchestrates multiple transcription factors with the Pol II apparatus for precise transcriptional control. However, its interplay with the surrounding chromatin remains poorly understood. Here, we analyze differential histone modifications between WT and MED23-/- (KO) cells and ...
ORGANISM(S): Mus musculus 
2015-09-16 | E-GEOD-59518 | biostudies-arrayexpress
UnknownBRD4 inhibition impairs DNA mismatch repair, induces mismatch repair mutation signatures and creates therapeutic vulnerability to immune checkpoint blockade in MMR-proficient tumors.
Not available
S-EPMC10124306 | biostudies-literature
ProteomicsHERD-1 Flag IP mass data in C.elegans
Proteins that may interact with HERD-1 were identified with Flag IP-mass in animals, which were tagged with 3xflag::GFP before the stat condon of HERD-1 in C.elegans.
ORGANISM(S): Caenorhabditis elegans 
2024-07-14 | PXD051885 | Pride
Herd-1 Ip mass C.elegans 
ProteomicsIdentification of protein interaction partners of SET-25 in Caenorhabditis elegans embryos using FLAG-tagged immunoprecipitation combined with liquid chromatography-tandem mass spectrometry (LC-MSMS)
Histone H3K9 trimethylation (H3K9me3) plays a pivotal role in the establishment and maintenance of heterochromatin and is essential for facilitating epigenetic inheritance. H3K9me3 is often biasedly deposited and associated with repetitive sequence regions, although the underlying mechanism remains ...
ORGANISM(S): Caenorhabditis elegans 
2026-02-25 | PXD072579 | Pride
Embryo C.elegans Lc-msms 
GenomicsThe Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation
The Mediator complex functions as a control center orchestrating diverse signalings, gene activities, and biological processes. However, how Mediator subunits determine distinct cell fates remains to be fully elucidated. Here, we show that Mediator MED23 controls the cell fate preference that direct...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-40369 | biostudies-arrayexpress
ProteomicsIdentification of ANXA1 as A Novel Upstream Negative Regulator of Notch1 Function in AML
Abnormal Notch1 expression has an important role in tumorigenesis. However, upstream control mechanisms for Notch1 are still insufficiently understood. Acute myeloid leukemia (AML) is one of the most common and lethal blood malignancies with limited possibilities for treatment. Thus, new therapeutic...
ORGANISM(S): Homo Sapiens 
2024-10-03 | PXD056593 |
GenomicsGenome wide association study of leprosy in Chinese population

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host genetic factors have been ...

phs000217.v1.p1 | EGA
TranscriptomicsA transcriptomic analysis of super-hybrid rice LYP9 and its parental lines
Using a whole-genome oligonucleotide microarray designed based on known and predicted indica rice genes, we investigated transcriptome profiles in developing leaves and panicles of super hybrid rice LYP9 and its parental cultivar 93-11 and PA64s. We detected 22,266 expressed genes out of 36,926 tota...
ORGANISM(S): Oryza sativa 
2009-04-22 | E-GEOD-14729 | biostudies-arrayexpress
ProteomicsTargeting the Galectin-7/TRPM2/Zn2+/DRP-1 Signaling Pathway: A Potential Therapeutic Intervention in the Pathogenesis of SJS/TEN
Targeting the Galectin-7/TRPM2/Zn2+/DRP-1 signaling pathway in keratinocyte presents a prospective therapeutic strategy for mitigating SJS/TEN in the future.
ORGANISM(S): Homo Sapiens 
2024-12-23 | PXD059206 |
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