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GenomicsETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas (ChIP-Seq I)
After characterizing super-enhancer-associated chromatin dynamics accompanied by malignant progression of skin stem cells, we show that ETS family members auto-regulate themselves and a cohort of cancer-associated super-enhancer transcription factors which together are essential for tumor maintenanc...
ORGANISM(S): Mus musculus 
2015-11-22 | E-GEOD-72145 | biostudies-arrayexpress
GenomicsETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas (ChIP-Seq II)
After characterizing super-enhancer-associated chromatin dynamics accompanied by malignant progression of skin stem cells, we show that ETS family members auto-regulate themselves and a cohort of cancer-associated super-enhancer transcription factors which together are essential for tumor maintenanc...
ORGANISM(S): Mus musculus 
2015-11-22 | E-GEOD-74867 | biostudies-arrayexpress
TranscriptomicsExpression data from squamous cell carcinoma stem cells, epidermal progenitor cells and hair follicle bulge stem cells
We used microarrays to assess the global gene expression profiles of cancer stem cells which were isolated from cutaneous squamous cell carcinomas which developed when WT, TGF beta receptor II ko, FAK KO, and TGF beta receptor II/FAK double KO were subjected to continuous DMBA treatment. Squamous ce...
ORGANISM(S): Mus musculus 
2011-12-30 | E-GEOD-29328 | biostudies-arrayexpress
TranscriptomicsETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas (RNA-Seq II)
After characterizing super-enhancer-associated chromatin dynamics accompanied by malignant progression of skin stem cells, we show that ETS family members auto-regulate themselves and a cohort of cancer-associated super-enhancer transcription factors which together are essential for tumor maintenanc...
ORGANISM(S): Mus musculus 
2015-11-22 | E-GEOD-74868 | biostudies-arrayexpress
GenomicsGenome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage [ChIP-Seq]
Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by stem cells (SCs). During the rest phase, the HF-SCs remain quiescent due to extrinsic inhibitory signals within the niche. As activating cues accumulate, HF-SCs become activated, proliferate, and gro...
ORGANISM(S): Mus musculus 
2011-09-02 | E-GEOD-31239 | biostudies-arrayexpress
TranscriptomicsETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas (RNA-Seq I)
After characterizing super-enhancer-associated chromatin dynamics accompanied by malignant progression of skin stem cells, we show that ETS family members auto-regulate themselves and a cohort of cancer-associated super-enhancer transcription factors which together are essential for tumor maintenanc...
ORGANISM(S): Mus musculus 
2015-11-22 | E-GEOD-72146 | biostudies-arrayexpress
GenomicsNFIB: A Governor of Epithelial-Melanocyte Stem Cell Behaviour in a Shared Niche
To identify direct NFIB target genes in HFSCs, we performed chromatin immunoprecipitation and deep sequencing (ChIP-seq) analysis using FACS-isolated HFSCs. Two independent NFIB ChIP-seq experiments were conducted.
ORGANISM(S): Mus musculus 
2013-02-07 | E-GEOD-42900 | biostudies-arrayexpress
GenomicsNfatc1 Orchestrates Aging in Hair Follicle Stem Cells
Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by hair follicle stem cells (HFSCs). We used ChIP-seq to unfold genome-wide chromatin landscapes of Nfatc1 and dissect the biological relevence of its upstream BMP signaling in HFSC aging. Telogen quies...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-52328 | biostudies-arrayexpress
TranscriptomicsEZH1 and EZH2 Co-Govern Histone H3-K27 Trimethylation and Are Essential for Hair Follicle Homeostasis and Wound Repair
Polycomb protein group (PcG)-dependent trimethylation on H3-K27(H3K27me3) regulates identity of embryonic stem cells (SCs). How H3K27me3 governs adult SCs and tissue development is unclear. Here, we conditionally target H3-K27-methyltransferases Ezh2 and Ezh1 to address their roles in mouse skin hom...
ORGANISM(S): Mus musculus 
2011-06-09 | E-GEOD-26616 | biostudies-arrayexpress
TranscriptomicsIdentification of stem cell populations in sweat glands and ducts: roles in homeostasis and wound repair
Sweat glands are abundant glands of our body and essential for thermoregulation. Like mammary glands, they originate from epidermal progenitors. However, they display few signs of cellular turnover, and whether they have stem cells and tissue regenerative capacity remain largely unexplored. Here we ...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-37274 | biostudies-arrayexpress
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