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ProteomicsProteomics of Fuchs Endothelial Corneal Dystrophy support that the extracellular matrix of Descemet¹s membrane is Disordered
Fuchs’ endothelial corneal dystrophy is major corneal disorder in the western world affecting the innermost part of the cornea, which leads to visual impairment. The morphological changes observed in Fuchs’ endothelial corneal dystrophy is well described, however, much less in known of the pathology...
ORGANISM(S): Homo sapiens (Human) 
2014-05-27 | PXD000746 | Pride
Itraq quantification Fuchs' endothelial corneal dystrophy Xic quantification 
TranscriptomicsExpression Profiling of Dll1 mutant mouse lines on different genetic background
The evolutionarily conserved Delta-Notch cell-cell signal-transduction pathway regulates the determination of various cell fates, which are important for the morphogenesis and development of numerous organs and tissues in many vertebrates and invertebrates. The Dll1 gene was mutated by homologous r...
ORGANISM(S): Mus musculus 
2009-01-01 | E-GEOD-11867 | biostudies-arrayexpress
TranscriptomicsGene regulation in brain, eye and heart of sighted C3H mice
It is unclear what role vision plays in guiding mouse behaviour, since the mouse eye is of comparably low optical quality, and mice are considered to rely primarily on other senses. All C3H substrains are homozygous for the Pde6b(rd1) mutation and get blind by weaning age. To study the impact of the...
ORGANISM(S): Mus musculus 
2010-05-23 | E-GEOD-7855 | biostudies-arrayexpress
TranscriptomicsExpression Profiling of Dll1 mutant mouse line
BACKGROUND: The Notch signaling pathway is an evolutionary conserved signal transduction pathway involved in embryonic patterning and regulation of cell fates during development and self-renewal. Recent studies have demonstrated that this pathway is integral to a complex system of interactions, invo...
ORGANISM(S): Mus musculus 
2009-03-01 | E-GEOD-12954 | biostudies-arrayexpress
TranscriptomicsLoss of the actin remodeler Eps8 causes calorie restriction and improved metabolic status in mice
In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan. Here we show that knockout mice for Eps8, a regulator of actin dynamics, display reduced bodyweight, partia...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-14454 | biostudies-arrayexpress
TranscriptomicsMultiple functions for Eya3 in mammalian organism
The important function of Eya (eyes absent) in eye development of D.melanogaster is well known, the function of its mammalian orthologs Eya1-4 is only partially understood. Yet, no phenotype for Eya2 and Eya3 in humans or mouse have been described. In our study we analysed new Eya-deficient mouse m...
ORGANISM(S): Mus musculus 
2008-12-17 | E-GEOD-9999 | biostudies-arrayexpress
TranscriptomicsEyeless: Pitx3 mutant mouse line, Expression profiling of liver
A new mouse mutant arose spontaneously at the 5th inbred generation in a congenic C3H/He line. Since the mice suffered from anophthalmia or microphthalmia, we referred to this new mutant as eyeless (provisional gene symbol: eyl). The mutation follows an autosomal recessive pattern of inheritance and...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-15336 | biostudies-arrayexpress
ProteomicsModel-driven analysis reveals oxidative stress adaptation enabling efficient energy utilization in a Crabtree-negative Saccharomyces cerevisiae.
The metabolic engineering of Saccharomyces cerevisiae to abolish the Crabtree effect via a pyruvate dehydrogenase bypass has enabled growth in minimal medium with glucose as the sole carbon source, although at a low growth rate. Adaptive laboratory evolution of the engineered strain (sZJD23), follow...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-02-13 | PXD074337 | Pride
Microbiology  saccharomyces cerevisiae  metabolism  crabtree 
UnknownLoss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis.
Not available
S-EPMC5777802 | biostudies-literature
UnknownIMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro.
Not available
S-EPMC7762174 | biostudies-literature
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