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The evolutionarily conserved ATP-dependent chromatin remodeling enzyme Fun30 has recently been shown to play important roles in heterochromatin silencing and DNA repair. However, how Fun30 remodels nucleosomes is not clear. Here we report a nucleosome sliding activity of Fun30 and its role in transc...
ORGANISM(S): Saccharomyces cerevisiae 
Chromosomal double-strand breaks (DSBs) are resected by 5M-bM-^@M-^Y-nucleases to form 3M-bM-^@M-^Y single-strand DNA (ssDNA) substrates for binding by homologous recombination and DNA damage checkpoint proteins. Two redundant pathways of extensive resection were described both in cells and in vitro...
ORGANISM(S): Saccharomyces cerevisiae 
The transcriptome of WT and fun30 mutant
Fun30 is the prototype of the Fun30-SMARCAD1-ETL sub-family of nucleosome remodelers involved in DNA repair and gene silencing. These proteins appear to act as single subunit nucleosome remodelers, but their molecular mechanisms are, at this point, poorly understood. Using multiple sequence alignmen...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-07-18 | PXD037249 | Pride
Role of Fun30 in chromatin remodelling and centromere function
To investigate the role of Fun30 in centromere establishment and function
ORGANISM(S): Saccharomyces cerevisiae 
Chromatin remodeling factors utilize ATP hydrolysis to modulate chromatin dynamics, and the Fun30-subfamily members in yeast and animals are a class of well-studied remodelers implicated in diverse biological processes. However, the molecular activity of plant Fun30 orthologues and their functions i...
ORGANISM(S): Arabidopsis thaliana 
2020-08-25 | GSE156722 | GEO
To investigate the role of Fun30 in centromere establishment and function. Part of experiments series: DNA-seq E-MTAB-759 and RNA-seq E-MTAB-955
ORGANISM(S): Saccharomyces cerevisiae 
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