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MetabolomicsPrediction of complex phenotypes using the Drosophila melanogaster metabolome
Understanding the genotype-phenotype map and how variation at different levels of biological organization is associated are central topics in modern biology. Fast developments in sequencing technologies and other molecular omic tools enable researchers to obtain detailed information on variation at ...
2021-08-05 | MTBLS2060 | MetaboLights
MetabolomicsGenome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a major risk factor leading to chronic liver disease and type 2 diabetes. Here we chart liver metabolic activity and functionality in NAFLD by integrating global transcriptomic data, from human liver biopsies, and metabolic flux data, measured across the ...
2016-12-15 | MTBLS298 | MetaboLights
MetabolomicsPREDICT: untargeted metabolomic profiling in a Brassica napus (canola) breeding population by GC-MS

Genome-wide association studies (GWAS) identified thousands of genetic loci associated with complex plant traits, including many traits of agronomical importance. However, functional interpretation of GWAS results remains challenging because of large candidate regions due to linkage disequilibriu...

2023-11-20 | MTBLS8056 | MetaboLights
TranscriptomicsGenome-wide tissue gene expression profiling in 1 year old Göttingen Minipigs with customized NimbleGen microarrays
Minipigs resemble many features of human anatomy, physiology, and biochemistry and represent an animal model for drug efficacy and safety testing. To evaluate at the molecular level the expression of drug targets, drug metabolism pathways or general features of organ transcriptomes in minipigs, we u...
ORGANISM(S): Sus scrofa 
2015-12-16 | E-GEOD-71438 | biostudies-arrayexpress
TranscriptomicsThree-dimensional folding and functional organization principles of the Drosophila genome
Chromosomes are the physical realization of genetic information and thus form the basis for its reading, hindering and propagation. Here we present a high-resolution chromosomal contact map derived from a new genome-wide chromosome conformation capture approach (a simplified version of the Hi-C meth...
ORGANISM(S): Drosophila melanogaster 
2012-01-20 | E-GEOD-34453 | biostudies-arrayexpress
TranscriptomicsGenome-wide tissue gene expression profiling in Juvenile Göttingen Minipigs with customized Agilent microarrays
Minipigs have favorable biological characteristics for juvenile toxicity studies to assess efficacy and safety of pediatric drug products. To evaluate at the molecular level the expression of drug targets, drug metabolism pathways or general maturation of organ transcriptomes in minipigs, we used Cu...
ORGANISM(S): Sus scrofa 
2015-12-16 | E-GEOD-71441 | biostudies-arrayexpress
UnknownGenome wide prediction of HNF4alpha functional binding sites by the use of local and global sequence context.
Not available
S-EPMC2374721 | biostudies-literature
GenomicsPrediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data
Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data
PRJNA512378 | ENA
TranscriptomicsActive chromatin domains are defined by acetylation islands revealed by genome-wide mapping
The identity and developmental potential of a human cell is specified by its epigenome that is largely defined by patterns of chromatin modifications including histone acetylation. Here we report high-resolution genome-wide mapping of diacetylation of histone H3 at Lys 9 and Lys 14 in resting and ac...
ORGANISM(S): Homo sapiens 
2007-02-05 | E-GEOD-6974 | biostudies-arrayexpress
GenomicsGenome-wide binding of the orphan nuclear receptor TR4 suggests its general role in fundamental biological processes
The orphan nuclear receptor TR4 (human testicular receptor 4 or NR2C2) plays a pivotal role in a variety of biological and metabolic processes. With no known ligand and few known target genes, the mode of TR4 function was unclear. We report the first genome-wide identification and characterization o...
ORGANISM(S): Homo sapiens 
2010-11-15 | E-GEOD-24685 | biostudies-arrayexpress
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