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MetabolomicsRedox proteomics reveal a role for peroxiredoxinylation in stress protection.

The redox state of proteins is essential for their function and guarantees cell fitness. Peroxiredoxins protect cells against oxidative stress, maintain redox homeostasis, act as chaperones, and transmit hydrogen peroxide signals to redox regulators. Despite the profound structural and functional...

2025-07-17 | MTBLS11979 | MetaboLights
MetabolomicsDeep functional analysis of synII, a 770 kb synthetic yeast chromosome
Here we report the design, construction and characterization of a 770 Kb synthetic yeast chromosome II (synII). With the UPLC-MS method, we demonstrated synII maintains a nearly wild-type phenotype and fitness despite hundreds of designer editing to it. Our phenomics, transcriptomics, proteomics dat...
2016-10-13 | MTBLS296 | MetaboLights
MetabolomicsProteomics and tracer metabolomics link GAPDH ISGylation to glycolytic control

Ubiquitin-like protein ISG15 (interferon-stimulated gene 15) has been implicated in the regulation of central carbon metabolism, but conflicting findings across experimental systems have limited mechanistic insight. Here, we applied a multi-omics approach in cells ectopically expressing the ISGyl...

2026-03-02 | MTBLS12619 | MetaboLights
MetabolomicsXiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via TGR5-FAK-RhoA/Rock signaling revealed by integrated metabolomics and proteomics

Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate diarrhea, but its mechanisms remain unclear. This study aimed to explore the underlying regulatory mechani...

2025-09-03 | MTBLS12931 | MetaboLights
MetabolomicsMulti-omics and biophysical phosphoproteomics uncover functional phosphorylation networks of BRAFV600E-driven signaling

Dysregulated kinase activity drives oncogenic signalling, perturbs cellular homeostasis, and promotes tumour progression. Despite major success in targeting kinases therapeutically, the downstream consequences of kinase inhibition and the mechanisms underlying drug resistance remain incompletely ...

2025-12-09 | MTBLS7390 | MetaboLights
GenomicsFunctional proteomics identified an upstream trancription complex promoting piRNA biogenesis
Functional proteomics identified an upstream trancription complex promoting piRNA biogenesis
PRJNA448738 | ENA
ProteomicsMannose-6-phosphate isomerase functional status shapes a rearrangement in the proteome and degradome of mannose-treated melanoma cells
Metabolic reprogramming is a ubiquitous feature of transformed cells, comprising one of the hallmarks of cancer and enabling neoplastic cells to adapt to new environments. Accumulated evidence reports on the failure of some neoplastic cells to convert mannose-6-phosphate into fructose-6-phosphate, t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-16 | MSV000094098 | MassIVE
TranscriptomicsTranscription profiling of neutrophils isolated by microfluidics: Clinical Microfluidics for Neutrophil Genomics and Proteomics
Neutrophils play critical roles in modulating the immune response. However, neutrophils have a short circulating half life, are readily stimulated in vitro, and have low levels of cellular mRNA when compared to other blood leukocyte populations. All of these factors have made it difficult to evaluat...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-22103 | biostudies-arrayexpress
GenomicsGenomics and proteomics analysis
Comparative genomics and secretome proteomics uncover the molecular basis of functional divergence in soybean-associated Bacillus
PRJEB120970 | ENA
UnknownCytoskeleton and nuclear lamina affection in recessive osteogenesis imperfecta: A functional proteomics perspective.
Not available
S-EPMC5584732 | biostudies-literature
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