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MetabolomicsDeep functional analysis of synII, a 770 kb synthetic yeast chromosome
Here we report the design, construction and characterization of a 770 Kb synthetic yeast chromosome II (synII). With the UPLC-MS method, we demonstrated synII maintains a nearly wild-type phenotype and fitness despite hundreds of designer editing to it. Our phenomics, transcriptomics, proteomics dat...
2016-10-13 | MTBLS296 | MetaboLights
MetabolomicsFunctional metabolomics as a tool to analyze Mediator function and structure in plants
Mediator is a multiprotein transcriptional co-regulator complex composed of four modules; Head, Middle, Tail, and Kinase. It conveys signals from promoter-bound transcriptional regulators to RNA polymerase II and thus plays an essential role in eukaryotic gene regulation. We describe subunit localiz...
2018-01-30 | MTBLS450 | MetaboLights
MetabolomicsMulti-omics and biophysical phosphoproteomics uncover functional phosphorylation networks of BRAFV600E-driven signaling

Dysregulated kinase activity drives oncogenic signalling, perturbs cellular homeostasis, and promotes tumour progression. Despite major success in targeting kinases therapeutically, the downstream consequences of kinase inhibition and the mechanisms underlying drug resistance remain incompletely ...

2025-12-09 | MTBLS7390 | MetaboLights
MetabolomicsIntegrated Metabolomics, Transcriptomics, and Functional Validation Reveal Oxidoreductase-Associated Strictinin Accumulation in Assam tea Germplasm
Strictinin, a bioactive hydrolyzable tannin in tea, accumulates at high levels in some Assam tea germplasms, yet the molecular basis underlying its variation remains unclear. Here, a rapid LC-MS/MS method was established for strictinin quantification and applied to profile 157 Assam tea accessions, ...
2026-08-03 | MTBLS14896 | MetaboLights
GenomicsSpatial transcriptomics reveals functional compartmentalization of mucinous colorectal adenocarcinoma
Spatial transcriptomics reveals functional compartmentalization of mucinous colorectal adenocarcinoma
PRJNA992207 | ENA
TranscriptomicsTranscriptomics profiling of Alzheimer's disease reveal novel molecular targets
Our data provide a comprehensive list of transcriptomics alterations and warrant holistic approach including both coding and non-coding RNAs in functional studies aimed to understand the pathophysiology of LOAD We performed directional RNA sequencing on high quality RNA samples extracted from hippoc...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-67333 | biostudies-arrayexpress
GenomicsSpatial transcriptomics reveals functional compartmentalization of estrogen receptor positive (ER+) breast cancer
Spatial transcriptomics reveals functional compartmentalization of estrogen receptor positive (ER+) breast cancer
PRJNA885881 | ENA
GenomicsCBTi-seq profiling spatially resolved single-cell transcriptomics in mouse brain functional areas
CBTi-seq profiling spatially resolved single-cell transcriptomics in mouse brain functional areas
PRJNA1298740 | ENA
GenomicsSpatially resolved transcriptomics reveals innervation-responsive functional cluster in skeletal muscle.
Spatially resolved transcriptomics reveals innervation-responsive functional cluster in skeletal muscle.
PRJNA816086 | ENA
TranscriptomicsTranscriptomics of Bacillus thuringiensis Strain CT-43.
We investigated the gene expression and metabolic regulatory mechanisms associated with the high-level accumulation of ICPs by performing the transcriptomics analysis of B. thuringiensis strain CT-43, using Illumina high throughout sequencing (RNA-seq) technique. The bacterial cells were collected a...
ORGANISM(S): Bacillus thuringiensis 
2013-04-17 | E-GEOD-39479 | biostudies-arrayexpress
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