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MetabolomicsCross-modal Integration of Metabolomics and Cardiac Functionality Captures Dynamic Metabotoxic Effects of Doxorubicin in Engineered Heart Tissues

Functional stem cell-derived heart models offer new avenues for preclinical, animal-free physiological assessment of drug cardiotoxicity. Yet, comprehensive molecular profiling in these models remains limited, leaving key metabolic drivers of cardiotoxicity unexplored.

Here, we leveraged an...

2025-12-07 | MTBLS13225 | MetaboLights
MetabolomicsCore microbes are ecological generalists supporting the host and ecosystem functionality and stability
Core gut microbes persist across diverse gut ecosystems, raising the central question in microbiome research of what defines core microbes and the factors driving their persistence across hosts? Using the rumen microbiome as a model system, our study reveals that core microbes exhibit distinct attri...
2025-05-23 | MTBLS11446 | MetaboLights
ProteomicsDecreased Fc fucosylation aligns with enhanced RSV-specific antibody functionality in adults compared to young children
Respiratory syncytial virus (RSV) is a major cause of severe respiratory tract infections in infants and older adults. While vaccines have recently been approved for older adults and pregnant women, vaccine development for infants remains challenging due to the risk of vaccine-enhanced disease. Unde...
ORGANISM(S): Homo sapiens (Human) 
2025-11-05 | PXD069590 | Pride
Fc-glycosylation Antibody maturation Respiratory virus Fc-functionality 
TranscriptomicsTranscription profiling of human and chimpanzee heart, brain, testis and lymphblastoid cell lines to study functionality of intergenic transcription.
Although a large proportion of human transcription occurs outside the boundaries of known genes, the functional significance of this transcription remains unknown. We have compared the expression patterns of known genes as well as intergenic transcripts within the ENCODE regions between humans and c...
ORGANISM(S): Homo sapiens 
2006-09-30 | E-TABM-136 | biostudies-arrayexpress
UnknownAqueous Blackcurrant Extract Improves Insulin Sensitivity and Secretion and Modulates the Gut Microbiome in Non-Obese Type 2 Diabetic Rats.
Not available
S-EPMC8150986 | biostudies-literature
GenomicsFunctionality of stripe factors on chromatin accessibility (RNA-Seq)
Functionality of stripe factors on chromatin accessibility (RNA-Seq)
PRJNA693309 | ENA
GenomicsFunctionality of stripe factors on chromatin accessibility (ATAC-Seq)
Functionality of stripe factors on chromatin accessibility (ATAC-Seq)
PRJNA693310 | ENA
GenomicsFunctionality of stripe factors on chromatin accessibility (ChIP-Seq)
Functionality of stripe factors on chromatin accessibility (ChIP-Seq)
PRJNA765328 | ENA
GenomicsNurr1 orchestrates claustrum development and functionality
Nurr1 orchestrates claustrum development and functionality
PRJNA1213827 | ENA
ProteomicsCross-organelle Coordination to Advance Plant Cytochrome P450 Functionality in Yeast
Sustainable production of plant secondary metabolites remains a significant challenge. Engineered yeast platforms offer a promising alternative, yet reconstituting plant cytochrome P450s (CYPs), key enzymes in these pathways, remains a major burden. Plant Membrane-Steroid-Binding Proteins (MSBPs) ha...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-09-22 | PXD060429 | Pride
Lc-msms Yeast 
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