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MetabolomicsPhosphoproteomic and Metabolomic Profiling Uncovers the Roles of CcPmk1 in the Pathogenicity of Cytospora chrysosperma

Pmk1, a highly conserved pathogenicity-related mitogen-activated protein kinase (MAPK) in pathogenic fungi, is phosphorylated and activated by MAP2K and acts as a global regulator of fungal infection and invasive growth by modulating downstream targets. However, the hierarchical CcPmk1 regulatory...

2022-07-11 | MTBLS4463 | MetaboLights
MetabolomicsAnalysis of the Mechanism of Pathogenicity Decline in Alternaria alternata f. sp. mali Mediated by the Mycovirus AaCV1
Apple leaf blotch disease caused by Alternaria alternata is a major fungal disease affecting apple production. To investigate the molecular mechanisms underlying virus-induced hypovirulence, metabolomic profiling was performed on A. alternata strains under different genetic and treatment conditions,...
2026-04-24 | MTBLS14366 | MetaboLights
MetabolomicsTrcrtB regulates carotenoids biosynthesis, stress tolerance, conidiation and pathogenicity in the postharvest pink rot fungus, Trichothecium roseum

Trichothecium roseum is a highly destructive postharvest pathogenic fungus that causes pink mold rot in various fruits and leads to significant agricultural and economic losses. While Phytoene is known to be crucial for phytopathogens, its roles in postharvest fungi, remain largely obsc...

2026-07-22 | MTBLS15120 | MetaboLights
MetabolomicsTargeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence
There is an urgent need to develop novel antifungals to tackle the threat that fungal pathogens pose to human health. In this work, we have performed a thorough characterisation and validation of the promising target methionine synthase. We have uncovered that in Aspergillus fumigatus the absence of...
2020-10-15 | MTBLS1636 | MetaboLights
TranscriptomicsFungal-Specific Transcription Factor AbPf2 Activates Pathogenicity in Alternaria brassicicola
Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Molecular determinants of its life style shift between saprophyte and pathogen, however, are unknown. To identify these determinants we studied nonpathogenic mutants of a transcription factor-coding gene, AbPf2. F...
ORGANISM(S): Alternaria brassicicola 
2013-09-30 | E-GEOD-38984 | biostudies-arrayexpress
ProteomicsIn-depth evaluation of the acetylome in major human fungal pathogens elucidates the essential role of lysine acetylation in regulation of fungal pathogenicity
Fungal pathogens cause deadly diseases in living organisms. Numerous studies suggest that lysine acetylation is a critical regulator in pathogenic fungi, but an in-depth and cross-species analysis of the acetylome in major pathogenic fungi is lacking, and our knowledge of the mechanism of acetylatio...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2019-04-29 | PXD010354 | Pride
Cryptococcus neoformans Virulence Protein posttranslational modification Human fungal pathogens Acetylation 
ProteomicsModifications of fungal membrane proteins profile under pathogenicity induction: a proteomic analysis of Botrytis cinerea membranome.
Botrytis cinerea is a model phytopathogenic fungus that infects more than 200 different relevant crops, thus being classified among the top ten fungal plant diseases. B. cinerea exhibits a wide arsenal of tools to infect plant tissues. Most of these factors are related to signal transduction cascade...
ORGANISM(S): Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea) Capsaspora owczarzaki 
2016-07-11 | PXD003099 | Pride
Botritys cinerea Proteomics Membranome Phytopathogenicity 
TranscriptomicsGlobal transcriptome analysis of the pH regulator pacC in Colletotrichum gloeosporioides
Colletotrichum gloeosporioides, a widely distributed economically important agent in postharvest fruit disease thrives by massive secretion of ammonia to alkalize its environment and activate its pathogenicity genes. We sequenced the C. gloeosporioides transcriptomes of WT and a M-bM-^HM-^FpacC muta...
ORGANISM(S): Colletotrichum gloeosporioides 
2013-11-21 | E-GEOD-41844 | biostudies-arrayexpress
ProteomicsA unique cell wall synthetic response evoked by glucosamine determines pathogenicity-associated fungal cellular differentiation
The yeast-to-hypha transition is tightly associated with pathogenicity in many human pathogenic fungi, such as the model fungal pathogen Cryptococcus neoformans, which is responsible for approximately 180,000 deaths annually. In this pathogen, the yeast-to-hypha transition can be initiated by distin...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2021-09-15 | PXD018015 | Pride
Yeast-to-hypha transition Cryptococcus neoformans Glucosamine Cell wall 
UnknownPhospholipase C-mediated calcium signalling is required for fungal development and pathogenicity in Magnaporthe oryzae.
Not available
S-EPMC6640429 | biostudies-literature
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