Sort   by:  
 Page size 
TranscriptomicsTranscriptome sequencing and comparative transcriptome analysis of the scleroglucan producer Sclerotium rolfsii
Two S. rolfsii transcriptomes obtained from scleroglucan-producing and scleroglucan-nonproducing conditions were pooled and sequenced using the 454 pyrosequencing technique yielding ~350,000 reads. These could be assembled into 21,937 contigs and 171,833 singletons, for which 6,951 had significant m...
ORGANISM(S): Athelia rolfsii 
2010-05-15 | E-GEOD-21040 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of the failing heart after myocardial infarction induction and doxorubicin treatment
The use of anthracycline antibiotics such as doxorubicin (DOX) has greatly improved the mortality and morbidity of cancer patients. However, the associated risk of cardiomyopathy has limited their clinical application. DOX-associated cardiotoxicity is irreversible and progresses to heart failure (HF...
ORGANISM(S): Rattus norvegicus 
2013-01-29 | E-GEOD-36239 | biostudies-arrayexpress
GenomicsGlobal genomic profiling of p53-regulated genes
p53 is a critical tumor suppressor and works as a stress-induced transcription factor to induce target genes mediating apoptosis, cell cycle arrest and senescence or other responses. To gain new insights into p53 biology, we used high-throughput sequencing to analyze global p53 transcriptional netwo...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-46240 | biostudies-arrayexpress
TranscriptomicsCompounds profiling on MCF7
The effects of several compounds on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling. Tested compounds: HSP90 inhibitors: 17AAG (Tanespimycin), NVP-AUY922, NMS-E973 (cpd developed at NMS). CDK inhibitors: CDK-887 (cpd developed at NMS). Topoisomerase inhibi...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-19638 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed genes after treatment with chemotherapy in breast cancer and their correlation with pathologic bad response (Miller & Payne grades 1 and 2)
The aim of this study was to compare the gene expression profile changes breast tumors after the treatment with Anthracyclines and Taxanes. To this end, an oligonucleotide microarray was performed (AffymetrixM-bM-^@M-^Ys HG-U133 Plus 2.0 array). This gene expression study was carried out on the biop...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-28826 | biostudies-arrayexpress
TranscriptomicsCardiotoxicity of tubulin binders
The use of tubulin binders (TBs) in oncology indications often is associated with cardiotoxicity, the mechanism of which has not been elucidated. We observed that a single administration of TBs to rats caused an increase in the number of mitotic figures in the myocardial interstitium after 24 hours...
ORGANISM(S): Rattus norvegicus 
2010-01-01 | E-GEOD-19290 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HT1080 fibrosarcoma cells treated with cytostatic drugs
HT1080 fibrosarcoma cells were treated with cytostatic drugs and analysed on Affymetrix microarray to identify genes and pathways regulated by these compounds. The array images were processed using Affymetrix MAS 5.0 software. and normalized by global scaling or scaled to a polyA+ spike mask
ORGANISM(S): Homo sapiens 
2008-04-01 | E-GEOD-2238 | biostudies-arrayexpress
TranscriptomicsPhenotypic, genomic and functional characterization reveals no differences between CD138++ and CD138low subpopulations in multiple myeloma cell lines (Copy Number)
Despite recent advances in the treatment of multiple myeloma (MM), it remains an incurable disease potentially due to the presence of resistant myeloma cancer stem cells (MM-CSC). Although the presence of clonogenic cells in MM was described more than 30 years ago, the phenotype of MM-CSC is still a...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-49483 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed genes after treatment with chemotherapy in breast cancer and their correlation with pathologic good response (Miller & Payne grades 4 and 5)
The aim of this study was to compare the gene expression profile changes breast tumors after the treatment with Anthracyclines and Taxanes. To this end, an oligonucleotide microarray was performed (AffymetrixM-bM-^@M-^Ys HG-U133 Plus 2.0 array). This gene expression study was carried out on the biop...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-28694 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed genes after treatment with chemotherapy in breast cancer and their correlation with pathologic mid-response (Miller & Payne grade 3)
The aim of this study was to compare the gene expression profile changes breast tumors after the treatment with Anthracyclines and Taxanes. To this end, an oligonucleotide microarray was performed (AffymetrixM-bM-^@M-^Ys HG-U133 Plus 2.0 array). This gene expression study was carried out on the biop...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-28583 | biostudies-arrayexpress
Sort   by:  
 Page size