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TranscriptomicsIdentification of a subtelomeric gene family expressed during the asexual-sexual stage transition in Plasmodium falciparum
For malaria transmission, the parasite must undergo sexual differentiation into mature gametocytes. However, the molecular basis for this critical transition in the parasites life cycle is unknown. Six previously uncharacterized genes, Pfg14.744, Pfg14.745, Pfg14.748, Pfg14.763, Pfg14.752 and Pfg6.6...
ORGANISM(S): Plasmodium falciparum 
2014-10-16 | E-GEOD-62364 | biostudies-arrayexpress
TranscriptomicsThe HAT Inhibitor Anacardic Acid Leads to Changes in Global Gene Expression During in vitro P.falciparum Development
To better understand the role of histone lysine acetylation in transcription in Plasmodium falciparum, we sought to attenuate the histone acetyltransferase (HAT) activity of PfGCN5 using anacardic acid (AA). We showed that AA reversibly and noncompetitively inhibited the HAT activity of recombinant ...
ORGANISM(S): Plasmodium falciparum 
2008-06-13 | E-GEOD-11763 | biostudies-arrayexpress
TranscriptomicsPlasmodium falciparum W2/Dd2 Day 8 gametocytes
The sexual stages are vital phases in malaria parasite transmission and are the targets of various interventions such as transmission blocking vaccines. The molecular mechanisms underlying sexual development, however, remain poorly understood. We report mappping of a determinant previously linked to...
ORGANISM(S): Plasmodium falciparum 
2010-06-10 | E-GEOD-2265 | biostudies-arrayexpress
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