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TranscriptomicsExpression profile of IL-1beta stimulated and non-stimulated endothelial cells
Complete identification of the bone marrow niche remains one of the most progressing fields. Attempts to identify soluble factors involved in stem cell renewal have been less successful. We have previously shown that endothelial cells (EC) can induce the long-term proliferation of hematopoietic prog...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-19240 | biostudies-arrayexpress
TranscriptomicsGene expression profiling upon PI3K inhibition using different inhibitors
Activation of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is one the most frequent genetic events in human cancer. Therefore, the development of PI3K inhibitors has attracted much attention. We previously described the pyrazolopyrimidine derivative ETP-45658 as a potent inhibitor of P...
ORGANISM(S): Homo sapiens 
2014-04-08 | E-GEOD-56579 | biostudies-arrayexpress
TranscriptomicsInference of pathways, non-coding RNAs and regulatory elements during iron deprivation of Synechocystis based on comprehensive expression profiling
Iron is an essential cofactor in many metabolic reactions. Mechanisms controlling iron homeostasis need to respond to changes in extracellular conditions, but must also keep the concentration of intracellular iron under strict control, as free ferrous iron (Fe2+) can lead to the generation of reacti...
ORGANISM(S): Synechocystis sp. PCC 6803 
2012-07-31 | E-GEOD-39804 | biostudies-arrayexpress
TranscriptomicsExpression data from RNA half-life experiments in Prochlorococcus
RNA decay was measured in Prochlorococcus after inhibition of transcription by rifampicin using customized Affymetrix gene expression arrays. RNA turnover plays an important role in the gene regulation of microorganisms and influences their speed of acclimation to environmental changes. We investiga...
ORGANISM(S): Prochlorococcus marinus subsp. pastoris str. CCMP1986 
2010-05-16 | E-GEOD-17075 | biostudies-arrayexpress
TranscriptomicsThe FtsH3 protease is an epistatic master regulator of the iron and phosphate stress responses in the cyanobacterium Synechocystis sp. PCC 6803
Regulation of gene expression is a sophisticated process leading to the activation or suppression of genes due to adaptation to environmental stimuli. The membrane-embedded FtsH proteases conserved in bacteria, chloroplasts and mitochondria, are involved in such regulation. The genome of the cyanoba...
ORGANISM(S): Synechocystis sp. PCC 6803 
2016-06-14 | E-GEOD-83303 | biostudies-arrayexpress
TranscriptomicsHost-virus transcriptome dynamics during infection of three cyanobacteria by a single phage reveals a unique regulatory program
Cyanobacteria are highly abundant in the oceans where they are constantly exposed to lytic viruses. Some viruses are restricted to a narrow host range while others infect a broad range of hosts. It is currently unknown whether broad-host range phages employ the same infection program, or regulate th...
ORGANISM(S): Synechococcus sp. WH 8102 
2015-08-30 | E-GEOD-63690 | biostudies-arrayexpress
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