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TranscriptomicsFyn-dependent prefrontal cortex gene networks in acute ethanol sensitivity
Fyn kinase has been implicated in multiple behavioral responses to ethanol and in the regulation of myelin gene expression. Here we tested whether Fyn kinase modulated basal or ethanol-responsive expression of genes regulated by acute ethanol in brain regions of the mesolimbocortical dopamine pathwa...
ORGANISM(S): Mus musculus 
2014-08-31 | E-GEOD-49028 | biostudies-arrayexpress
GenomicsTranscriptomic consequence of Fyn knock-out in glioblastoma
Transcriptomic consequence of Fyn knock-out in glioblastoma
PRJNA843080 | ENA
TranscriptomicsRNA-seq of human non-small-cell lung cancer cell line A549 treated with Feiyanning
We performed RNA seq to elucidate differential gene expression in A549 treated with Feiyanning (FYN). A549 cells were treated with FYN, then cultured for 24 h. Total RNA were extracted using TrizoI, and mRNA were retain using Oligotex mRNA Mini kit. The mRNA were fragmented into small fragments a...
ORGANISM(S): Homo sapiens 
2021-08-09 | E-MTAB-10821 | biostudies-arrayexpress
ProteomicsSrc heterodimerically activates Lyn or Fyn to serve as targets for esophageal squamous cell carcinoma (ESCC) diagnosis and treatment
we combined phosphoproteomics and several cellular and molecular biologic strategies to identify that Src specifically interacted with the members of Src-family kinases (SFKs), such as Fyn or Lyn to form heterodimers, and subsequently phosphorylate the tyrosine sites in SH2 and kinase domains, which...
ORGANISM(S): Homo Sapiens 
2022-03-15 | PXD032306 |
GenomicsFYN-TRAF3IP2 activating fusion oncogene in peripheral T-cell lymphoma
FYN-TRAF3IP2 activating fusion oncogene in peripheral T-cell lymphoma
PRJNA575793 | ENA
GenomicsRNA-seq data related to FYN-TRAF3IP2 mouse model
FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T cell lymphoma, not otherwise specified
PRJEB42764 | ENA
ProteomicsFyn- and Abl-driven interactome and post-translational modifications of DCBLD1 and DCBLD2
Three related datasets are included, all from immunoprecipitations of FLAG-tagged DCBLD1 and DCBLD2 (human) from 293 cells. Letters at the end of file names denote regions of each gel lave from highest (“A”) to lowest (“B”-X) molecular weight. File names containing “SILAC” are part of a dataset comp...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Homo sapiens (Human) 
2020-08-07 | PXD017723 | Pride
Clcp1 Dcbld2 Esdn Dcbld1 
TranscriptomicsTranscriptomic consequence of Fyn knock-out in glioblastoma
To investigate the role of Fyn in glioblastoma, transcriptomic comparison between WT and Fyn-KO glioblastoma was done by bulk RNA sequencing.
ORGANISM(S): Mus musculus 
2021-11-30 | GSE188771 | GEO
TranscriptomicsFyn-dependent prefrontal cortex gene networks in acute ethanol sensitivity
Fyn kinase has been implicated in multiple behavioral responses to ethanol and in the regulation of myelin gene expression. Here we tested whether Fyn kinase modulated basal or ethanol-responsive expression of genes regulated by acute ethanol in brain regions of the mesolimbocortical dopamine pathwa...
ORGANISM(S): Mus musculus 
2014-08-31 | GSE49028 | GEO
TranscriptomicsFYN-TRAF3IP2 activating fusion oncogene in peripheral T-cell lymphoma
FYN-TRAF3IP2 expression in hematopoietic progenitors induces T cell transformation in mice and cooperates with loss of the Tet2 tumor suppressor in PTCL development. To investigate the oncogenic activity of FYN-TRAF3IP2, we analyzed the lymphomagenic effects of expressing this gene fusion alone and ...
ORGANISM(S): Mus musculus 
2020-10-01 | GSE138416 | GEO
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