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ProteomicsSWATH-proteomics analysis of ibrutinib mechanism of action in neutropenia and acute myeloid leukemia initiating mutated granulocyte-colony stimulating factor receptor
Neutrophil production and function are primarily determined by granulocyte colony stimulating factor receptor (G-CSFR). G-CSFRs associated mutations (mostly localized in the transmembrane and cytoplasmic domains of the receptor) have been reported with several distinct hematological abnormalities as...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-27 | PXD013402 | Pride
Btk inhibitor Swath 32d G-csfr 
UnknownTuning of G-CSFR signaling by de novo-designed agonists.
Not available
S-EPMC12628175 | biostudies-literature
UnknownSWATH-Proteomics of Ibrutinib's Action in Myeloid Leukemia Initiating Mutated G-CSFR Signaling.
Not available
S-EPMC7492401 | biostudies-literature
ProteomicsPhosphoproteomics analysis of normal and mutated granulocyte colony stimulating factor receptors
Granulocyte colony stimulating factor receptor (G-CSFR) plays important role in the production of neutrophils from hematopoietic stem cells. Mutated form of the receptor has been directly associated with two distinct malignant phenotype in patients, e.g. acute myeloid leukemia (AML) and chronic neut...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-14 | PXD009311 | Pride
Phosphoproteomics Silac G-csfr signaling 
ProteomicsG-CSFR expression is not essential for neutrophil differentiation but for progenitor formation and emergency neutrophil responses
Severe congenital neutropenia (SCN) is a rare disorder characterized by a maturation arrest of myeloid progenitor cells in the bone marrow and severe reduction in the amount of circulating neutrophils. Loss-of-function mutations in the CSF3R (the gene encoding the granulocyte colony-stimulating fact...
ORGANISM(S): Homo sapiens (Human) 
2020-09-25 | PXD018178 | Pride
Phagocytes Granulocytes And myelopoiesis 
TranscriptomicsG-CSF receptor targeting in inflammatory arthritis
G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation and function. We developed a neutralizing monoclonal antibody to the murine G-CSF receptor (G-CSFR), which antagonizes binding of murine G-CSF and inhibits G-CSFR signallin...
ORGANISM(S): Mus musculus 
2016-01-19 | E-GEOD-76966 | biostudies-arrayexpress
UnknownThe RNA m<sup>6</sup>A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression.
Not available
S-EPMC10757716 | biostudies-literature
ProteomicsTime resolved quantitative phospho-tyrosine analysis reveals Bruton’s Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors
Granulocyte-colony stimulating factor receptor (G-CSFR) controls myeloid progenitor proliferation and differentiation to neutrophils. Mutations in CSF3R (encoding G-CSFR) have been reported in patients with chronic neutrophilic leukemia (CNL) and acute myeloid leukemia (AML); however, despite years ...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-11 | PXD009662 | Pride
Aml Ruxolitinib Silac Ibrutinib Phosphoproteomics Cnl Lc-ms/ms 
UnknownA JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation.
Not available
S-EPMC11342096 | biostudies-literature
UnknownSuppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor.
Not available
S-EPMC1847666 | biostudies-literature
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