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ProteomicsMutation-specific and common phosphotyrosine signatures of KRAS G12D and G13D alleles
KRAS is one of the most frequently mutated genes across all cancer subtypes. Two of the most frequent oncogenic KRAS mutations observed in patients result in glycine to aspartic acid substitution at either codon 12 (G12D) or 13 (G13D). Although the biochemical differences between these two predomina...
ORGANISM(S): Homo sapiens (Human) 
2021-06-09 | PXD009843 | Pride
Sw48 Phosphoproteome G13d mutation G12d mutation Kras Signaling 
TranscriptomicsExpression data comparing KRas(G12D/+);CreT, R26(H1047R/+);KRas(G12D/+);CreT, and MMTV-Neu mouse mammary tumors
Breast Cancer (BC) has been associated with alterations in signaling through a number of growth factor and hormone regulated pathways. Mouse models for metastatic BC have been developed using oncoproteins that activate PI3K, Stat3 and Ras signaling. To determine the role of each pathway, we analyz...
ORGANISM(S): Mus musculus 
2015-09-16 | E-GEOD-73073 | biostudies-arrayexpress
TranscriptomicsGene expression analysis between the pancreatic tissues of Pdx1-cre;Kras LSL-G12D and Pdx-cre;KrasLSL-G12D;IKK2/beta F/F mice
Constitutive Kras and NF-kB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). Here, we report that pancreas-targeted IKK2/beta inactivation inhibited NF-kB activation and completely suppressed PDAC development. Our findings demonstrated that NF-kB is...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-33322 | biostudies-arrayexpress
TranscriptomicsEffect of DNMT3A R882H mutation or WT on gene expression in hematopoietic stem/progenitor cells with NRAS G12D co-transduction (Microarray)
DNA Methyltransferase 3A (DNMT3A) is frequently mutated in various hematopoietic malignancies; however, the underlying oncogenic mechanisms remain elusive. Here, we report that DNMT3A mutational â??hotspotâ?? at Arg882 (i.e., DNMT3A-R882H) cooperates with constitutively activated RAS in transforming...
ORGANISM(S): Mus musculus 
2016-06-23 | E-GEOD-71437 | biostudies-arrayexpress
TranscriptomicsGene expression differences between the pancreatic tissues of Pdx1-Cre;KrasLSL-G12D and Pdx1-Cre;KrasLSL-G12D;IKK2/betaF/F mice
Constitutive Kras and NF-kappaB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms of constitutive NF-kappaB activation in KrasG12D-induced PDAC are not yet understood. Here, we report that pancreas-targeted IKK2/beta inactivat...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-27478 | biostudies-arrayexpress
GenomicsRNA sequencing of SW1990 KRAS-G12D or KRAS-G12D/K128R knockin cell lines
RNA sequencing of SW1990 KRAS-G12D or KRAS-G12D/K128R knockin cell lines
PRJNA1089940 | ENA
TranscriptomicsGene expression profiling by DNA microarray in Colo741 cell line transfected by KRas-G12D or KRas-G12V
Mutations of the proto-oncogene KRas, together with the inactivation of the onco-suppressor genes APC and TP53, are considered to have an important role both in the carcinogenesis and in the colorectal tumor progression. The oncogene K-ras has activating mutations, especially in codon 12, in about ...
ORGANISM(S): Homo sapiens 
2008-12-17 | E-GEOD-12398 | biostudies-arrayexpress
GenomicsEffect of DNMT3A R882H mutation or WT expression on epigenetic landscapes of hematopoietic stem/progenitor cells with NRAS G12D co-transduction (ChIP-seq)
DNA Methyltransferase 3A (DNMT3A) is frequently mutated in various hematopoietic malignancies; however, the underlying oncogenic mechanisms remain elusive. Here, we report that DNMT3A mutational ‘hotspot’ at Arg882 (DNMT3A-R882H) cooperates with constitutively activated RAS in transforming murin...
ORGANISM(S): Mus musculus 
2016-06-23 | E-GEOD-71472 | biostudies-arrayexpress
GenomicsEffect of DNMT3A R882H mutation or WT expression on global DNA methylation patterns of hematopoietic stem/progenitor cells with NRAS G12D co-transduction (eRRBS)
DNA Methyltransferase 3A (DNMT3A) is frequently mutated in various hematopoietic malignancies; however, the underlying oncogenic mechanisms remain elusive. Here, we report that DNMT3A mutational ‘hotspot’ at Arg882 (DNMT3A-R882H) cooperates with constitutively activated RAS in transforming murin...
ORGANISM(S): Mus musculus 
2016-06-23 | E-GEOD-71473 | biostudies-arrayexpress
GenomicsKRAS WT and G12D overexpression RNA-seq
KRAS WT and G12D overexpression RNA-seq
PRJNA512870 | ENA
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