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Increased G3BP2-Tau interaction in Tauopathies is a natural defense against Tau aggregation
Many RNA-binding proteins (RBPs), particularly those associated with RNA granules, promote pathological protein aggregation in neurodegenerative diseases. Here, we demonstrate that G3BP2, a core component of stress granules, directly interacts with Tau and inhibits Tau aggregation. In the human brai...
ORGANISM(S): Homo sapiens 
2023-05-17 | GSE226624 | GEO
Nonopore sequencing of circRNAs and G3BP2-RIP sequencing in HCC827 cells
Molecular glue degraders (MGDs) are small molecule compounds that repurpose the ubiquitin-proteasome system to induce degradation of challenging therapeutic targets. Thalidomide-analogs are clinically effective MGDs that bind cereblon (CRBN), a substrate receptor of the Cullin-4/RING E3 ubiquitin li...
ORGANISM(S): Homo sapiens (Human) 
2026-01-14 | PXD064243 | Pride
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