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ProteomicsLow-melting point agarose as embedding medium for MALDI mass spectrometry imaging and laser-capture microdissection-based proteomics
We report an investigation of low-temperature embedding media in terms of their mechanical properties and embedding temperature, with the goal of determining a reliable embedding medium for the combination of MALDI MSI of lipids, laser-capture microdissection of tissue regions, and quantitative prot...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD045349 | Pride
Proteomics Laser-capture microdissection Maldi msi Embedding media 
MetabolomicsA mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights
UnknownTemporal trends and treatment patterns in anal fissure management: insights from a multicenter study in Italy.
Not available
S-EPMC11452494 | biostudies-literature
UnknownCardiac surgery practice during the COVID-19 outbreak: a multicentre national survey.
Not available
S-EPMC7989504 | biostudies-literature
UnknownOxygenation improvement and duration of prone positioning are associated with ICU mortality in mechanically ventilated COVID-19 patients.
Not available
S-EPMC11775368 | biostudies-literature
UnknownCenter-Related Determinants of VKA Anticoagulation Quality: A Prospective, Multicenter Evaluation.
Not available
S-EPMC4670074 | biostudies-literature
GenomicsAlzheimer's Disease Sequencing Project (ADSP)

The overarching goals of the ADSP are to: (1) identify new genomic variants contributing to increased risk of developing AD, (2) identify new genomic variants contributing to protection against developing AD, and (3) provide insight as to why individuals with known risk factor variants escape fro...

phs000572.v1.p1 | EGA
UnknownTocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial.
Not available
S-EPMC7576974 | biostudies-literature
UnknownGlobal hospital-based disease management of acute diverticulitis: a prospective, international cohort study.
Not available
S-EPMC12512976 | biostudies-literature
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