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ProteomicsGAIN domain cleavage of aGPCRs requires multiple domain-extrinsic factors coordinated by the 7TM region
The G protein-coupled receptor (GPCR) autoproteolysis-inducing (GAIN) domain is a structurally conserved and tell-tale fold of class B2/adhesion GPCRs (aGPCRs). Self-cleavage of the GAIN domain is central for mechanobiological and signaling properties of aGPCRs. Biochemical analyses and atomistic de...
ORGANISM(S): Homo sapiens (Human) 
2025-10-01 | PXD056561 | Pride
Adhesion gpcr Photo-crosslinking Gain domain 
TranscriptomicsGain of the oncostatin M receptor in cervical squamous cell carcinoma is associated with adverse clinical outcome [camb1Mb data]
For many oncogenes, increased expression resulting from copy number gain confers a selective advantage to cells that consequently make up the tumour bulk. To identify oncogenes of potential biological significance in cervical squamous cell carcinoma (SCC), 36 primary samples and ten cell lines were ...
ORGANISM(S): Homo sapiens 
2011-02-16 | E-GEOD-27332 | biostudies-arrayexpress
TranscriptomicsGain of the oncostatin M receptor in cervical squamous cell carcinoma is associated with adverse clinical outcome [penn1Mb data]
For many oncogenes, increased expression resulting from copy number gain confers a selective advantage to cells that consequently make up the tumour bulk. To identify oncogenes of potential biological significance in cervical squamous cell carcinoma (SCC), 36 primary samples and ten cell lines were ...
ORGANISM(S): Homo sapiens 
2011-02-16 | E-GEOD-27331 | biostudies-arrayexpress
TranscriptomicsRelevance of Chromosome 2p Gain in Early Binet Stage A Chronic Lymphocytic Leukemia (expression)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by chromosomal aberrations of prognostic significance. Recent studies showed that gain of chromosome 2p is a recurrent lesion in CLL. We investigated the 2p gain and its relationship with prognostic biomarkers in ...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-38611 | biostudies-arrayexpress
ProteomicsSynaptamide activates the adhesion GPCR GPR110 through conformational changes induced by GAIN domain binding
Ligand-induced conformational changes of GPR110 in cells probed by chemical cross-linking and mass specrtometry
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD017128 | Pride
Gpr110 In-cell cross-linking Conformational changes Gain domain Lc-ms/ms 
GenomicsGain-of-function ENL YEATS domain mutations impede nephrogenesis through gene expression control [Spatial Transcriptomics]
Gain-of-function ENL YEATS domain mutations impede nephrogenesis through gene expression control [Spatial Transcriptomics]
PRJNA1193649 | ENA
GenomicsGain-of-function ENL YEATS domain mutations impede nephrogenesis through gene expression control [RNA-seq]
Gain-of-function ENL YEATS domain mutations impede nephrogenesis through gene expression control [RNA-seq]
PRJNA1106455 | ENA
UnknownGeneric residue numbering of the GAIN domain of adhesion GPCRs.
Not available
S-EPMC11697300 | biostudies-literature
UnknownQuantifying the mechanisms of domain gain in animal proteins.
Not available
S-EPMC2926785 | biostudies-literature
GenomicsGain-of-function ENL YEATS domain mutations impede nephrogenesis through gene expression control
Gain-of-function ENL YEATS domain mutations impede nephrogenesis through gene expression control
PRJNA1193642 | ENA
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