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GenomicsGenome-wide gain-of-function screening characterized lncRNAs as tumor immune response regulators [CRISPR_screen]
Genome-wide gain-of-function screening characterized lncRNAs as tumor immune response regulators [CRISPR_screen]
PRJNA834778 | ENA
GenomicsGenome-wide gain-of-function screening characterized lncRNAs as tumor immune response regulators
Genome-wide gain-of-function screening characterized lncRNAs as tumor immune response regulators
PRJNA834651 | ENA
TranscriptomicsToxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss
FUS is an RNA-binding protein involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS-containing aggregates are often associated with concomitant loss of nuclear FUS. Whether loss of nuclear FUS function, gain of a cytoplasmic function, or a combination of ...
ORGANISM(S): Mus musculus 
2016-03-14 | E-GEOD-78730 | biostudies-arrayexpress
TranscriptomicsExpression data of Xrx1 gain and loss of function experiments from early Xenopus laevis embryos (stage 13)
Eye development is a multistep process that requires specific inductive signals and precise morphogenetic movements, starting early during development in the eye-field, a well-definite region of the anterior neural plate. It has been demonstrated that a gene network of eye field transcription factor...
ORGANISM(S): Xenopus laevis 
2013-09-23 | E-GEOD-35918 | biostudies-arrayexpress
TranscriptomicsClassification of a frameshift/extended and a stop mutation in WT1 as gain of function mutations which activate cell cycle genes and promote Wilms tumor cell proliferation
The Wilms tumor 1 (WT1) gene encodes a zinc finger transcription factor important for normal kidney development. WT1 is a suppressor for Wilms tumor development and an oncogene for diverse malignant tumors. We recently established cell lines from primary Wilms tumors and identified the corresponding...
ORGANISM(S): Homo sapiens 
2014-05-12 | E-GEOD-54635 | biostudies-arrayexpress
UnknownChromosome-segment scanning for gain- or loss-of-function screening (CHASING).
Not available
S-EPMC12146616 | biostudies-literature
UnknownGain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation.
Not available
S-EPMC8748537 | biostudies-literature
TranscriptomicsSomatic Gain-of-Function mTOR mutation in Clonally Expanded T-lymphocytes Associated with Chronic Graft-Versus-Host Disease
Graft-versus-host-disease (GvHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HSCT). Here we report studies of a patient with chronic GVHD (cGVHD) carrying persistent CD4+ T cell clonal expansion which harbored somatic mTOR, NFKB2, and TLR2 mutations. Functional an...
ORGANISM(S): Homo sapiens 
2020-04-12 | E-MTAB-8911 | biostudies-arrayexpress
TranscriptomicsMicroarray gene expression data from Hdh knock-out, wild-type and knock-in embryonic stem cells
Huntington's disease (HD) features a unique disease-initiating mechanism hypothesized to entail an impact of the CAG repeat encoded polyglutamine region on the full-length huntingtin protein, with dominant effects that are continuous with CAG size, in a simple gain of function. To evaluate these pre...
ORGANISM(S): Mus musculus 
2011-05-04 | E-GEOD-26001 | biostudies-arrayexpress
TranscriptomicsEffects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men
Polyphenolic compounds, such as resveratrol, have recently received widespread interest due to their ability to mimic effects of calorie restriction. The objective of the present study was to gain more insight into the effects of 30 days resveratrol supplementation on adipose tissue morphology and u...
ORGANISM(S): Homo sapiens 
2013-09-25 | E-GEOD-42432 | biostudies-arrayexpress
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