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TranscriptomicsExpression data from human embryonic (9-12w) and post-natal livers
The liver is a multifunctional organ, which undergoes rapid changes during the developmental period and relies on tightly-regulated gene expression. Little is known regarding the complex expression patterns of mRNAs during the early stages of human liver development in comparison to post-natal liver...
ORGANISM(S): Homo sapiens 
2009-10-01 | E-GEOD-15238 | biostudies-arrayexpress
TranscriptomicsHepatocellular carcinomas (HCC) in mice transduced in utero with feline immunodeficiency virus-based vectors (CGH)
Fetal mice (16 days gestation) were administered FIV-based lentiviral viral particles containing the gene encoding EGFP. Six liver tumors developed in three mice (1 male, 2 females) between the ages of 273 and 484 days, each mouse developed 2 tumors. These tumors and non-tumorous liver tissue from ...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-25900 | biostudies-arrayexpress
TranscriptomicsHepatocellular carcinomas (HCC) in mice transduced in utero with feline immunodeficiency virus-based vectors (expression)
Fetal mice (16 days gestation) were administered feline immunodeficiency virus (FIV)-based lentiviral viral particles containing the gene encoding GFP. Six liver tumors developed in three mice between the ages of 273 and 484 days, each mouse developed 2 tumors. These tumors and non-tumorous liver t...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-19306 | biostudies-arrayexpress
TranscriptomicsChronic liver inflammation-induced double strand DNA breaks enhance hepatocarcinogenesis
Surgical resection is the preferred treatment for Hepatocellular carcinoma; however, it induces tumor recurrence. Our objective was to understand the molecular mechanisms linking liver regeneration under chronic-inflammation to tumorigenesis. Mdr2-knockout mice, a model of inflammation-associated ca...
ORGANISM(S): Mus musculus 
2010-01-03 | E-GEOD-14539 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of MDR2 knockout mice vs heterozygotes sampled at multiple time points in the early stages of liver carcinogenesis to identify the molecular mechanisms of HCC initiation and promotion
We studied the molecular mechanisms of hepatocellular carcinoma (HCC) initiation and promotion using the Mdr2-knockout (Mdr2-KO) mice at pre-cancerous stages of liver disease. These mice lack the liver-specific P-glycoprotein responsible for phosphatidylcholine transport across the canalicular membr...
ORGANISM(S): Mus musculus 
2007-11-23 | E-GEOD-4612 | biostudies-arrayexpress
TranscriptomicsSpecific Genomic and Transcriptomic Aberrations in Tumors Induced by Partial Hepatectomy of a Chronically Inflamed Murine Liver [aCGH]
Background & Aims. Resection of hepatocellular carcinoma (HCC) tumors by partial hepatectomy (PHx) is associated with promoting hepatocarcinogenesis. We have previously reported that PHx promotes hepatocarcinogenesis in the Mdr2-knockout (Mdr2-KO) mouse, a model for inflammation-mediated HCC. Now, w...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-61423 | biostudies-arrayexpress
TranscriptomicsSpecific Genomic and Transcriptomic Aberrations in Tumors Induced by Partial Hepatectomy of a Chronically Inflamed Murine Liver [expression]
Background & Aims. Resection of hepatocellular carcinoma (HCC) tumors by partial hepatectomy (PHx) is associated with promoting hepatocarcinogenesis. We have previously reported that PHx promotes hepatocarcinogenesis in the Mdr2-knockout (Mdr2-KO) mouse, a model for inflammation-mediated HCC. Now, w...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-61422 | biostudies-arrayexpress
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