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MetabolomicsX-ray Irradiation Suppresses Keloid Growth by Inducing G2/M Arrest via the Phytosphingosine-KIF20A Axis
Keloid radiotherapy is clinically effective but has an incomplete underlying molecular mechanism and limited accessibility; we used X-ray exposure to identify effector pathways replicating its antifibrotic benefits without further radiation. After collecting patient keloid samples, primary human kel...
2026-06-06 | MTBLS14461 | MetaboLights
ProteomicsGamma ray irradiation of epithelial carcinoma cells under hypoxic conditions
We demonstrate for the first time that under hypoxic conditions, A431 epithelial carcinoma cells exhibit increased viability when exposed to low-dose γ-irradiation, indicating that radiotherapy can promote tumor cell survival when oxygen supply is limited. When assessed using iTRAQ quantitative prot...
ORGANISM(S): Homo sapiens (Human) 
2017-02-27 | PXD003937 | Pride
Cancer Hypoxia Itraq Radiotherapy Calcium signaling pathway 
TranscriptomicsExpression data in mouse liver exposed to low dose-rate radiation
Expression profiles in mouse liver exposed to long-term gamma-irradiation were examined to assess in vivo effects of low dose-rate radiation. Three groups of male C57BL/6J mice were exposed to whole body irradiation at dose-rates of 17-20 mGy/day, 0.86-1.0 mGy/day or 0.042-0.050 mGy/day for 401-485 ...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-20562 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Norwegian spruce embryos exposed to gamma radiation
Conifers such as Picea abies (Norway spruce) are among the most radiosensitive plant species, yet the molecular impact of ionising radiation on their stem cells remains poorly understood. This study examines the transcriptomic response of embryogenic stem cells to gamma radiation, focusing on mechan...
ORGANISM(S): Picea abies 
2025-07-14 | E-MTAB-15297 | biostudies-arrayexpress
TranscriptomicsGene expression profile of bone marrow with post-irradiation radioprotector
To elucidate the mechanism of the in vivo radioprotection activity of Zn-containing heat-treated Saccharomyces cerevisiae yeast (Zn-yeast), expression changes in bone marrow after whole body irradiation (WBI) with concomitant treatment of Zn-yeast were analyzed using microarray technology. Keywords...
ORGANISM(S): Mus musculus 
2010-09-27 | E-GEOD-18727 | biostudies-arrayexpress
TranscriptomicsT-cell lymphoblastic lymphomas induced by gamma-irradiation
This SuperSeries is composed of the following subset Series: GSE10858: Comparative Genomic hybridization of gamma-irradiated T-cell lymphomas GSE10859: Expression patterns of cDNAs in gamma-irradiation induced T-cell lymphomas GSE10891: Gamma-irradiation induced T-cell lymphomas (miRNA study) Keywor...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10861 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for LGR5hi and LGR5lo ISCs in response to gamma-irradiation
To check gene expression signatures for LGR5hi and LGR5lo ISCs in response to gamma-irradiation, we performed whole genome microarray on LGR5hi and LGR5lo ISCs purified from irradiated mice or non-irradiated mice Radiation induced gene expression in LGR5hi and LGR5lo ISCs of LGR5-GFPki mice was mea...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-49461 | biostudies-arrayexpress
TranscriptomicsLow Dose Gamma Irradiation of Trypanosoma evansi Parasites Identifies Molecular Changes That Ooccur to Repair Radiation Damage and Gene Transcripts That May be Involved in Establishing Disease in Mice Post Irradiation
The protozoan parasite Trypanosoma evansi is responsible for causing Surra in a variety of mammalian hosts over a wide geographical area. In order to identify which genes and processes are required to establish disease in mice, parasites were irradiated over a range using a Cobalt60 gamma source. A...
ORGANISM(S): Trypanosoma evansi 
2022-05-10 | E-MTAB-11705 | biostudies-arrayexpress
TranscriptomicsGamma-irradiation induced T-cell lymphomas (miRNA study)
This set of data contains the expression levels of cDNAs in T-cell lymphoblastic lymphomas induced by gamma-irradiation. These tumor samples were compared to normal thymuses Keywords: Tumor profiles, comparison of tumoral versus wild-type tissues, lymphomas and leukemias C57BL/6J animals were mainta...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10891 | biostudies-arrayexpress
ProteomicsGamma ray irradiation of epithelial carcinoma cells under hypoxic conditions
We demonstrate for the first time that under hypoxic conditions, A431 epithelial carcinoma cells exhibit increased viability when exposed to low-dose ?-irradiation, indicating that radiotherapy can promote tumor cell survival when oxygen supply is limited. When assessed using iTRAQ quantitative prot...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080784 | MassIVE
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