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Differentiated somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by forced expression of four transcription factors—Oct4, Sox2, Klf4, and c-Myc. However, it remains undetermined whether the reprogrammed iPS cells are fully pluripotent, resembling normal embryonic stem (ES...
ORGANISM(S): Mus musculus 
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
The mechanisms responsible for weight loss-induced improvement in insulin sensitivity are partially understood. Greater insight can now be achieved through deep phenotyping and data integration. Here, we used an integrative approach to investigate associations between changes in insulin sensitivity ...
2021-02-11 | MTBLS653 | MetaboLights
The newly discovered 5-hydroxymethylcytosine (5hmC) may complicate previous observations of abnormal cytosine methylation statuses used for the identification of new tumor suppressor gene candidates relevant to human hepatocarcinogenesis. The simultaneous detection of 5mC and 5hmC will stimulate the...
ORGANISM(S): Homo sapiens 
Comparative analysis was performed at both nucleic acid and protein vaccine levels to provides a reference for the "glycosylation quality control" of SARS-CoV-2 RBD vaccines. For instance, monitoring the glycoform distribution at the N343 site (e.g., ensuring the proportion of the M5 glycoform is ≥3...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD076685 | Pride
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