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TranscriptomicsInduced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.
Multiple FTD patient-specific iPSC lines were generated for the first time, Human neurons of progranulin haploinsufficiency have been established. PGRN S116X neurons are more sensitive to kinase inhibitors-induced cell stress, which can be rescued by ectopic progranulin expression, revealing progran...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-40378 | biostudies-arrayexpress
ProteomicsA Fkh1/2 binding site array in the WHI5 promoter drives sub-scaling transcription
Cells typically regulate their size within a relatively tight range by coupling growth to the cell division cycle using a dedicated set of molecular mechanisms. In budding yeast, cells are born with a similar amount of the G1/S inhibitor protein Whi5 that is then diluted by growth throughout G1. As ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-03-31 | PXD075635 | Pride
Whi5 Cell size Size scaling 
UnknownRare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection.
Not available
S-EPMC5552316 | biostudies-literature
UnknownA management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC).
Not available
S-EPMC7210240 | biostudies-literature
GenomicsWhole Genome and Exon Capture Sequencing of Bladder Cancers

One primary bladder cancer and paired peripheral blood sample were subjected to whole genome sequencing on an Illumina HiSeq 2000 platform. This technology was utilized to investigate the genetic basis of a durable remission of metastatic bladder cancer in a patient treated with everolimus, a dru...

phs000535.v1.p1 | EGA
UnknownLow Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study.
Not available
S-EPMC4747478 | biostudies-literature
UnknownRisk factors for poor visual outcome in patients with idiopathic intracranial hypertension.
Not available
S-EPMC4553022 | biostudies-literature
UnknownThe Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.
Not available
S-EPMC6075733 | biostudies-literature
UnknownCell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.
Not available
S-EPMC5957518 | biostudies-literature
UnknownWhole-genome characterization of lung adenocarcinomas lacking the RTK/RAS/RAF pathway.
Not available
S-EPMC8009291 | biostudies-literature
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