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ProteomicsHSPA4 restrains transferrin in dopaminergic neurons to attenuate ferroptosis in a Parkinson’s disease model
Heat shock protein A4 (HSPA4) is a molecular chaperone belonging to the heat shock protein 70 (HSP70) family. This study aims to investigate the antiferroptotic effects of HSPA4 in a Parkinson’s disease (PD) model and explore the underlying mechanisms. Here we show that HSPA4 overexpression reduces ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD067550 | Pride
Dopaminergic neurons Hspa4 Parkinson’s disease Ferroptosis Transferrin 
ProteomicsFlag-GABPα overexpression HEK293T cells LC-MS/MS
Immunoprecipitated by Flag and IgG antibody for protein capture by LC-MS/MS in HEK293T cells infected with GABPα-Flag overexpression plasmid.
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD070466 | Pride
Hek293t cells Gabpα Lc-ms/ms 
ProteomicsDDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding
Hyaline cartilage fibrosis is one of the important reasons for the poor prognosis of advanced osteoarthritis (OA), and is the main factor leading to joint stiffness and deformity. However, the mechanism of hyaline cartilage fibrosis remains largely unclear. Here we found that DDX5, one of the foundi...
ORGANISM(S): Mus Musculus 
2024-03-13 | PXD050571 |
ProteomicsAn essential maternal PADI6-UHRF1-UBE2D (MPU) complex regulates protein ubiquitination during oocyte maturation and embryogenesis
100 WT or Padi6Null MII oocytes for MS samples from three independent experiments and IP samples in 500 MII oocytes from one experiment were used for Mass spectrometry analysis.
ORGANISM(S): Mus Musculus 
2025-01-25 | PXD060230 |
ProteomicsThe subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3
The subcortical maternal complex (SCMC) is essential for the maintenance of female fertility in mammals. Most pathogenic mutations in SCMC-encoding genes result in female reproductive failure characterized by early embryonic arrest. Assembled in oocytes, the SCMC maintains the normal cleavage of ear...
ORGANISM(S): Mus Musculus Spodoptera Frugiperda 
2024-09-03 | PXD055498 |
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