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TranscriptomicsLoss of heat shock protein HSPA4 aggravates pressure overload-induced myocardial damage
Failure of molecular chaperones to direct the correct folding of newly synthesized proteins leads to the accumulation of misfolded proteins in cells. HSPA4 is a member of the heat shock protein 110 family (HSP110) that acts as a nucleotide exchange factor of HSP70 chaperones. We found that the expre...
ORGANISM(S): Mus musculus 
2012-10-10 | E-GEOD-32885 | biostudies-arrayexpress
ProteomicsHSPA4 restrains transferrin in dopaminergic neurons to attenuate ferroptosis in a Parkinson’s disease model
Heat shock protein A4 (HSPA4) is a molecular chaperone belonging to the heat shock protein 70 (HSP70) family. This study aims to investigate the antiferroptotic effects of HSPA4 in a Parkinson’s disease (PD) model and explore the underlying mechanisms. Here we show that HSPA4 overexpression reduces ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD067550 | Pride
Dopaminergic neurons Hspa4 Parkinson’s disease Ferroptosis Transferrin 
TranscriptomicsLoss of heat shock protein HSPA4 aggravates pressure overload-induced myocardial damage
Failure of molecular chaperones to direct the correct folding of newly synthesized proteins leads to the accumulation of misfolded proteins in cells. HSPA4 is a member of the heat shock protein 110 family (HSP110) that acts as a nucleotide exchange factor of HSP70 chaperones. We found that the expre...
ORGANISM(S): Mus musculus 
2012-10-10 | GSE32885 | GEO
UnknownUnveiling the potential of HSPA4: a comprehensive pan-cancer analysis of HSPA4 in diagnosis, prognosis, and immunotherapy.
Not available
S-EPMC10911360 | biostudies-literature
UnknownSignificant correlation between HSPA4 and prognosis and immune regulation in hepatocellular carcinoma.
Not available
S-EPMC8555498 | biostudies-literature
UnknownHSPA4 upregulation induces immune evasion via ALKBH5/CD58 axis in gastric cancer.
Not available
S-EPMC11000359 | biostudies-literature
UnknownHSPA4 restrains transferrin in dopaminergic neurons to attenuate ferroptosis in a Parkinson's disease model.
Not available
S-EPMC12511602 | biostudies-literature
GenomicsMus musculus
Loss of heat shock protein HSPA4 aggravates pressure overload-induced myocardial damage
PRJNA146617 | ENA
UnknownHSPA4 Is a Biomarker of Placenta Accreta and Enhances the Angiogenesis Ability of Vessel Endothelial Cells.
Not available
S-EPMC9143901 | biostudies-literature
UnknownUpregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma.
Not available
S-EPMC4366630 | biostudies-literature
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