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ProteomicsProteomic analyses of iron deprived NK92 cells with deferoxamine or PPMX-T003
This work aims to detect the differentially expressed proteins between transferrin receptor 1 inhibition and iron chelation in a natural killer cell lymphoma-derived cell line NK92. Cells were treated with 500 μM deferoxamine or 10 μg/mL PPMX-T003 (an anti-transferrin receptor 1 inhibitory antibody)...
ORGANISM(S): Homo Sapiens (human) 
2025-07-04 | PXD059223 | JPOST Repository
ProteomicsHuman holo-transferrin glycation
Understanding the effect of glycation on the function of transferrin, the systemic iron transporter, is fundamental to fully grasp the mechanisms leading to the loss of iron homeostasis observed in diabetes mellitus (DM). The spontaneous reaction with protein amino groups is one of the main causes o...
ORGANISM(S): Homo sapiens (Human) 
2018-05-30 | PXD009345 | Pride
Post-translational modification Holo-transferrin Blood serum Glycation Lc-ms/ms 
TranscriptomicsThe transferrin receptor is required for intestinal epithelial homeostasis
The role of Tfr1 in non-erythroid tissues remains elusive due to the embryonic lethality of the Tfr1 global knockout mouse model. To bypass this problem, we generated a mouse model in which Tfr1 was conditionally deleted in intestinal epithelial cells (IECs). These mice developed severe IEC disrup...
ORGANISM(S): Mus musculus 
2015-05-19 | E-GEOD-68984 | biostudies-arrayexpress
TranscriptomicsMechanism of cell death induced by saporin
Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1 These studies detail transcriptional changes induced in cancer cells by the complex of saporin (b-SO6) and the antibody fusion protein ch128.1Av...
ORGANISM(S): Homo sapiens 
2012-11-09 | E-GEOD-42138 | biostudies-arrayexpress
ModelsYoon2017 - Mathematical Modeling of Mutant Transferrin-CRM107 Molecular Conjugates for Cancer Therapy
Mathematical modeling of mutant transferrin-CRM107 molecular conjugates for cancer therapy. Yoon DJ1, Chen KY1, Lopes AM1, Pan AA1, Shiloach J2, Mason AB3, Kamei DT4. Author information 1 Department of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, 5121 Engineering V...
2020-01-09 | MODEL1912160006 | BioModels
ProteomicsIron flux in plasmacytoid dendritic cells; potential role for transferrin receptor beyond iron metabolism
Plasmacytoid dendritic cells (pDCs) are critical antiviral sentinels known for rapid type I interferon (IFN-I) production. However, their proteomic profile and nutrient dependencies are not well understood. Here, we used absolute quantitative proteomics of ex vivo murine splenic pDCs to characterize...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD079623 | Pride
Transferrin receptor  dendritic cell  iron 
TranscriptomicsTranscription profiling of T. brucei bloodstream forms cultured in different proportions of fetal bovine serum to investigate iron-sensing mechanisms
Bloodstream trypanosomes are sensitive to iron starvation, and upregulate ESAG6/7 transferrin receptor (TfR) mRNA and protein levels when placed in low transferrin or iron-depleted media, and adjust TfR expression to compensate for reduced endocytosis. Both observations suggest a specific transcript...
ORGANISM(S): Trypanosoma brucei 
2008-06-26 | E-MEXP-1530 | biostudies-arrayexpress
ProteomicsHSPA4 restrains transferrin in dopaminergic neurons to attenuate ferroptosis in a Parkinson’s disease model
Heat shock protein A4 (HSPA4) is a molecular chaperone belonging to the heat shock protein 70 (HSP70) family. This study aims to investigate the antiferroptotic effects of HSPA4 in a Parkinson’s disease (PD) model and explore the underlying mechanisms. Here we show that HSPA4 overexpression reduces ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD067550 | Pride
Dopaminergic neurons Hspa4 Parkinson’s disease Ferroptosis Transferrin 
TranscriptomicsTranscription profiling of Neisseria meningitidis strain MC58 grown on RPMI agar containing 10uM Transferrin, 10uM Lactoferrin, 1uM Haemoglobin, or 20uM Ferric chloride
Transcriptional profiling of Neisseria meningitidis strain MC58 grown on RPMI agar containing 10uM Transferrin, 10uM Lactoferrin, 1uM Haemoglobin, or 20uM Ferric chloride.
ORGANISM(S): Neisseria meningitidis 
2009-02-25 | E-MEXP-1143 | biostudies-arrayexpress
MetabolomicsFatal COVID-19 pulmonary disease involves ferroptosis.

SARS-CoV-2 infection causes severe pulmonary manifestations, with poorly understood mechanisms and limited treatment options. Hyperferritinemia and disrupted lung iron homeostasis in COVID-19 patients imply that ferroptosis, an iron-dependent cell death, may occur. Immunostaining and lipidomic an...

2024-07-11 | MTBLS3107 | MetaboLights
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